SODM_ALTAL
ID SODM_ALTAL Reviewed; 25 AA.
AC P86254;
DT 23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 23-MAR-2010, sequence version 1.
DT 03-AUG-2022, entry version 30.
DE RecName: Full=Superoxide dismutase [Mn], mitochondrial {ECO:0000250|UniProtKB:P04179};
DE EC=1.15.1.1 {ECO:0000250|UniProtKB:P0A0J3};
DE AltName: Full=Manganese-dependent superoxide dismutase;
DE Short=MnSOD;
DE AltName: Allergen=Alt a MnSOD;
DE Flags: Fragment;
OS Alternaria alternata (Alternaria rot fungus) (Torula alternata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; Alternaria;
OC Alternaria sect. Alternaria; Alternaria alternata complex.
OX NCBI_TaxID=5599;
RN [1]
RP PROTEIN SEQUENCE, ALLERGEN, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=CBS 104.26;
RX PubMed=21255138; DOI=10.1111/j.1365-2222.2010.03671.x;
RA Postigo I., Gutierrez-Rodriguez A., Fernandez J., Guisantes J.A., Sunen E.,
RA Martinez J.;
RT "Diagnostic value of Alt a 1, fungal enolase and manganese-dependent
RT superoxide dismutase in the component-resolved diagnosis of allergy to
RT pleosporaceae.";
RL Clin. Exp. Allergy 41:443-451(2011).
CC -!- FUNCTION: Destroys superoxide anion radicals which are normally
CC produced within the cells and which are toxic to biological systems.
CC {ECO:0000250|UniProtKB:P04179}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 H(+) + 2 superoxide = H2O2 + O2; Xref=Rhea:RHEA:20696,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240,
CC ChEBI:CHEBI:18421; EC=1.15.1.1;
CC Evidence={ECO:0000250|UniProtKB:P0A0J3};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000250|UniProtKB:P04179};
CC Note=Binds 1 Mn(2+) ion per subunit. {ECO:0000250|UniProtKB:P04179};
CC -!- SUBUNIT: Homotetramer. {ECO:0000250|UniProtKB:P04179}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC {ECO:0000250|UniProtKB:P04179}.
CC -!- ALLERGEN: Causes an allergic reaction in humans. Binds to IgE.
CC {ECO:0000269|PubMed:21255138}.
CC -!- MISCELLANEOUS: On the 2D-gel the determined pI of this protein is: 7,
CC its MW is: 24 kDa.
CC -!- MISCELLANEOUS: Could be used for the diagnosis of allergy to
CC Pleosporaceae.
CC -!- SIMILARITY: Belongs to the iron/manganese superoxide dismutase family.
CC {ECO:0000255}.
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DR AlphaFoldDB; P86254; -.
DR SMR; P86254; -.
DR Allergome; 11425; Alt a 14.0101.
DR Allergome; 8737; Alt a 14.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004784; F:superoxide dismutase activity; IEA:UniProtKB-EC.
DR Gene3D; 1.10.287.990; -; 1.
DR InterPro; IPR019831; Mn/Fe_SOD_N.
DR InterPro; IPR036324; Mn/Fe_SOD_N_sf.
DR Pfam; PF00081; Sod_Fe_N; 1.
DR SUPFAM; SSF46609; SSF46609; 1.
PE 1: Evidence at protein level;
KW Allergen; Antioxidant; Direct protein sequencing; Manganese; Metal-binding;
KW Mitochondrion; Oxidoreductase.
FT CHAIN <1..>25
FT /note="Superoxide dismutase [Mn], mitochondrial"
FT /id="PRO_0000392637"
FT BINDING 9
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000250|UniProtKB:P04179"
FT NON_TER 1
FT NON_TER 25
SQ SEQUENCE 25 AA; 2711 MW; 4A47F8A2C717C6D6 CRC64;
FNAGGHINHS LFWQNLAPAS SNEAK