SODM_MYCCE
ID SODM_MYCCE Reviewed; 138 AA.
AC P53643;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=Superoxide dismutase [Mn];
DE EC=1.15.1.1;
DE Flags: Fragment;
GN Name=sodA; Synonyms=sod;
OS Mycobacterium celatum.
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=28045;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 51130 / CDC 89-0444 / Type 1, and NCTC 12882 / Type 3;
RA Bull T.J., Shanson D.C., Archard L.C.;
RT "Rapid identification of mycobacteria from AIDS patients by capillary
RT electrophoretic profiling of amplified SOD gene.";
RL Clin. Mol. Pathol. 48:124-132(1995).
CC -!- FUNCTION: Destroys superoxide anion radicals which are normally
CC produced within the cells and which are toxic to biological systems.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 H(+) + 2 superoxide = H2O2 + O2; Xref=Rhea:RHEA:20696,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240,
CC ChEBI:CHEBI:18421; EC=1.15.1.1;
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
CC Note=Binds 1 Mn(2+) ion per subunit. {ECO:0000250};
CC -!- SIMILARITY: Belongs to the iron/manganese superoxide dismutase family.
CC {ECO:0000305}.
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DR EMBL; Z48215; CAA88248.1; -; Genomic_DNA.
DR EMBL; Z48209; CAA88242.1; -; Genomic_DNA.
DR PIR; S52360; S52360.
DR PIR; S52362; S52362.
DR AlphaFoldDB; P53643; -.
DR SMR; P53643; -.
DR STRING; 28045.AWB95_21805; -.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004784; F:superoxide dismutase activity; IEA:UniProtKB-EC.
DR Gene3D; 1.10.287.990; -; 1.
DR Gene3D; 3.55.40.20; -; 1.
DR InterPro; IPR001189; Mn/Fe_SOD.
DR InterPro; IPR019832; Mn/Fe_SOD_C.
DR InterPro; IPR019831; Mn/Fe_SOD_N.
DR InterPro; IPR036324; Mn/Fe_SOD_N_sf.
DR InterPro; IPR036314; SOD_C_sf.
DR Pfam; PF02777; Sod_Fe_C; 1.
DR Pfam; PF00081; Sod_Fe_N; 1.
DR PRINTS; PR01703; MNSODISMTASE.
DR SUPFAM; SSF46609; SSF46609; 1.
DR SUPFAM; SSF54719; SSF54719; 1.
PE 3: Inferred from homology;
KW Manganese; Metal-binding; Oxidoreductase.
FT CHAIN <1..>138
FT /note="Superoxide dismutase [Mn]"
FT /id="PRO_0000160046"
FT BINDING 1
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000250"
FT BINDING 49
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000250"
FT BINDING 133
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000250"
FT BINDING 137
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000250"
FT VARIANT 32
FT /note="V -> I (in strain: NCTC 12882)"
FT VARIANT 120
FT /note="S -> T (in strain: NCTC 12882)"
FT NON_TER 1
FT NON_TER 138
SQ SEQUENCE 138 AA; 15241 MW; 2B106CE775207D42 CRC64;
HHSKHHATYV KGANDALEKL EEARAKDDQS TVLLNEKNLA FNLAGHVNHT IWWKNLSPNG
GDKPTGELAA AIDDAFGSFD KFRAQFHAAA TTVQGSGWAA LGWDNLGEKL LIFQVYDHQS
NFPLGVVPLL LLDMWEHA