ID   SODM_MYCIA              Reviewed;         207 AA.
AC   P46728; H8IJN4;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2012, sequence version 3.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Superoxide dismutase [Mn];
DE            EC=1.15.1.1;
GN   Name=sodA; Synonyms=sod; OrderedLocusNames=OCU_01930;
OS   Mycobacterium intracellulare (strain ATCC 13950 / DSM 43223 / JCM 6384 /
OS   NCTC 13025 / 3600).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=487521;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13950 / DSM 43223 / JCM 6384 / NCTC 13025 / 3600;
RX   PubMed=22535933; DOI=10.1128/jb.00295-12;
RA   Kim B.J., Choi B.S., Lim J.S., Choi I.Y., Lee J.H., Chun J., Kook Y.H.,
RA   Kim B.J.;
RT   "Complete genome sequence of Mycobacterium intracellulare strain ATCC
RT   13950T.";
RL   J. Bacteriol. 194:2750-2750(2012).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 27-189.
RC   STRAIN=ATCC 13950 / DSM 43223 / JCM 6384 / NCTC 13025 / 3600;
RX   PubMed=7852575; DOI=10.1128/jcm.32.11.2801-2812.1994;
RA   Zolg J.W., Philippi-Schulz S.;
RT   "The superoxide dismutase gene, a target for detection and identification
RT   of mycobacteria by PCR.";
RL   J. Clin. Microbiol. 32:2801-2812(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 28-165.
RC   STRAIN=ATCC 35847 / TMC 1476 / Serotype 7, and BC9405/90 / Serotype 18;
RA   Bull T.J., Shanson D.C., Archard L.C.;
RT   "Rapid identification of mycobacteria from AIDS patients by capillary
RT   electrophoretic profiling of amplified SOD gene.";
RL   Clin. Mol. Pathol. 48:124-132(1995).
CC   -!- FUNCTION: Destroys superoxide anion radicals which are normally
CC       produced within the cells and which are toxic to biological systems.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H(+) + 2 superoxide = H2O2 + O2; Xref=Rhea:RHEA:20696,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240,
CC         ChEBI:CHEBI:18421; EC=1.15.1.1;
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
CC       Note=Binds 1 Mn(2+) ion per subunit. {ECO:0000250};
CC   -!- SIMILARITY: Belongs to the iron/manganese superoxide dismutase family.
CC       {ECO:0000305}.
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DR   EMBL; CP003322; AFC41413.1; -; Genomic_DNA.
DR   EMBL; X81387; CAA57150.1; -; Genomic_DNA.
DR   EMBL; Z48218; CAA88251.1; -; Genomic_DNA.
DR   EMBL; Z48217; CAA88250.1; -; Genomic_DNA.
DR   PIR; S52372; S52372.
DR   RefSeq; WP_007771867.1; NZ_ABIN01000150.1.
DR   AlphaFoldDB; P46728; -.
DR   SMR; P46728; -.
DR   STRING; 487521.OCU_01930; -.
DR   EnsemblBacteria; AFC41413; AFC41413; OCU_01930.
DR   GeneID; 31527606; -.
DR   GeneID; 66743164; -.
DR   KEGG; mia:OCU_01930; -.
DR   PATRIC; fig|487521.10.peg.195; -.
DR   eggNOG; COG0605; Bacteria.
DR   HOGENOM; CLU_031625_2_2_11; -.
DR   OMA; KWGSFDK; -.
DR   Proteomes; UP000008004; Chromosome.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004784; F:superoxide dismutase activity; IEA:UniProtKB-EC.
DR   Gene3D; 1.10.287.990; -; 1.
DR   Gene3D; 3.55.40.20; -; 1.
DR   InterPro; IPR001189; Mn/Fe_SOD.
DR   InterPro; IPR019833; Mn/Fe_SOD_BS.
DR   InterPro; IPR019832; Mn/Fe_SOD_C.
DR   InterPro; IPR019831; Mn/Fe_SOD_N.
DR   InterPro; IPR036324; Mn/Fe_SOD_N_sf.
DR   InterPro; IPR036314; SOD_C_sf.
DR   Pfam; PF02777; Sod_Fe_C; 1.
DR   Pfam; PF00081; Sod_Fe_N; 1.
DR   PIRSF; PIRSF000349; SODismutase; 1.
DR   PRINTS; PR01703; MNSODISMTASE.
DR   SUPFAM; SSF46609; SSF46609; 1.
DR   SUPFAM; SSF54719; SSF54719; 1.
DR   PROSITE; PS00088; SOD_MN; 1.
PE   3: Inferred from homology;
KW   Manganese; Metal-binding; Oxidoreductase.
FT   CHAIN           1..207
FT                   /note="Superoxide dismutase [Mn]"
FT                   /id="PRO_0000160050"
FT   BINDING         28
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000250"
FT   BINDING         76
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000250"
FT   BINDING         160
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000250"
FT   BINDING         164
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000250"
FT   VARIANT         28
FT                   /note="H -> S (in strain: BC9405/90 / Serotype 18)"
FT   VARIANT         30
FT                   /note="S -> T (in strain: ATCC 35847 / Serotype 7)"
FT   VARIANT         98
FT                   /note="A -> T (in strain: BC9405/90 / Serotype 18)"
FT   VARIANT         135
FT                   /note="N -> S (in strain: ATCC 35847 / Serotype 7)"
FT   CONFLICT        27
FT                   /note="I -> L (in Ref. 2; CAA57150)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        188
FT                   /note="A -> D (in Ref. 2; CAA57150)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   207 AA;  23131 MW;  A4FE9F20DB54695E CRC64;
     MAEYTLPDLD WDYAALEPHI SGQINEIHHS KHHATYVKGV NDALSKLEEA RANEDHAAIF
     LNEKNLAFHL GGHVNHSIWW KNLSPDGGDK PTGELAAAID DAFGSFDRFR AQFSAAANGL
     QGSGWAVLGY DTLGNRLLTF QLYDQQANVP LGIIPLLQVD MWEHAFYLQY KNVKADYVKA
     FWNVVNWADV QKRYAAATSK TQGLIFG