SODM_MYCSC
ID SODM_MYCSC Reviewed; 163 AA.
AC P50913;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=Superoxide dismutase [Mn];
DE EC=1.15.1.1;
DE Flags: Fragment;
GN Name=sodA; Synonyms=sod;
OS Mycobacterium scrofulaceum.
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1783;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 19981 / DSM 43992 / JCM 6381 / NCTC 10803 / TMC 1323;
RX PubMed=7852575; DOI=10.1128/jcm.32.11.2801-2812.1994;
RA Zolg J.W., Philippi-Schulz S.;
RT "The superoxide dismutase gene, a target for detection and identification
RT of mycobacteria by PCR.";
RL J. Clin. Microbiol. 32:2801-2812(1994).
CC -!- FUNCTION: Destroys superoxide anion radicals which are normally
CC produced within the cells and which are toxic to biological systems.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 H(+) + 2 superoxide = H2O2 + O2; Xref=Rhea:RHEA:20696,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240,
CC ChEBI:CHEBI:18421; EC=1.15.1.1;
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
CC Note=Binds 1 Mn(2+) ion per subunit. {ECO:0000250};
CC -!- SIMILARITY: Belongs to the iron/manganese superoxide dismutase family.
CC {ECO:0000305}.
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DR EMBL; X81389; CAA57152.1; -; Genomic_DNA.
DR AlphaFoldDB; P50913; -.
DR SMR; P50913; -.
DR STRING; 1783.BST44_27715; -.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004784; F:superoxide dismutase activity; IEA:UniProtKB-EC.
DR Gene3D; 1.10.287.990; -; 1.
DR Gene3D; 3.55.40.20; -; 1.
DR InterPro; IPR001189; Mn/Fe_SOD.
DR InterPro; IPR019833; Mn/Fe_SOD_BS.
DR InterPro; IPR019832; Mn/Fe_SOD_C.
DR InterPro; IPR019831; Mn/Fe_SOD_N.
DR InterPro; IPR036324; Mn/Fe_SOD_N_sf.
DR InterPro; IPR036314; SOD_C_sf.
DR Pfam; PF02777; Sod_Fe_C; 1.
DR Pfam; PF00081; Sod_Fe_N; 1.
DR PIRSF; PIRSF000349; SODismutase; 1.
DR PRINTS; PR01703; MNSODISMTASE.
DR SUPFAM; SSF46609; SSF46609; 1.
DR SUPFAM; SSF54719; SSF54719; 1.
DR PROSITE; PS00088; SOD_MN; 1.
PE 3: Inferred from homology;
KW Manganese; Metal-binding; Oxidoreductase.
FT CHAIN <1..>163
FT /note="Superoxide dismutase [Mn]"
FT /id="PRO_0000160058"
FT BINDING 2
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000250"
FT BINDING 50
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000250"
FT BINDING 134
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000250"
FT BINDING 138
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000250"
FT NON_TER 1
FT NON_TER 163
SQ SEQUENCE 163 AA; 18149 MW; 57766E43E0EA4777 CRC64;
LHHSKHHATY VKGVNDAVAK LQEARANDDH AAIFLNEKNL AFHLGGHVNH SIWWKNLSPD
GGDKPTGELA AAIDDAFGSF DKFRAQFSAA ANGLQGSGWA VLGYDTLGSR LLTFQLYDQQ
ANVPLGIIPL LQVDMWEHAF YLQYKNVKAD YVKAFWNVVN WAE