SOEM_CAEEL
ID SOEM_CAEEL Reviewed; 190 AA.
AC Q7YWN4;
DT 07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Protein soem-1 {ECO:0000305};
DE AltName: Full=Suppressor of ectopic mig-13 {ECO:0000303|PubMed:27780040};
GN Name=soem-1 {ECO:0000303|PubMed:27780040};
GN ORFNames=Y87G2A.17 {ECO:0000312|WormBase:Y87G2A.17};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, INTERACTION WITH ABL-1, TISSUE SPECIFICITY, AND MUTAGENESIS OF
RP HIS-140.
RX PubMed=27780040; DOI=10.1016/j.devcel.2016.09.029;
RA Zhu Z., Chai Y., Jiang Y., Li W., Hu H., Li W., Wu J.W., Wang Z.X.,
RA Huang S., Ou G.;
RT "Functional coordination of WAVE and WASP in C. elegans neuroblast
RT migration.";
RL Dev. Cell 39:224-238(2016).
CC -!- FUNCTION: Functions downstream of migratory protein mig-13 and may play
CC a role in the control of Q neuroblast migration during larval
CC development. {ECO:0000269|PubMed:27780040}.
CC -!- SUBUNIT: Interacts with abl-1. {ECO:0000269|PubMed:27780040}.
CC -!- TISSUE SPECIFICITY: Expressed in PQR, but not AQR, Q neuroblast
CC descendents. {ECO:0000269|PubMed:27780040}.
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DR EMBL; BX284601; CAE18040.1; -; Genomic_DNA.
DR RefSeq; NP_001021833.1; NM_001026662.3.
DR AlphaFoldDB; Q7YWN4; -.
DR SMR; Q7YWN4; -.
DR PaxDb; Q7YWN4; -.
DR EnsemblMetazoa; Y87G2A.17.1; Y87G2A.17.1; WBGene00013603.
DR EnsemblMetazoa; Y87G2A.17.2; Y87G2A.17.2; WBGene00013603.
DR GeneID; 3565861; -.
DR KEGG; cel:CELE_Y87G2A.17; -.
DR UCSC; Y87G2A.17; c. elegans.
DR CTD; 3565861; -.
DR WormBase; Y87G2A.17; CE35142; WBGene00013603; soem-1.
DR eggNOG; ENOG502SA57; Eukaryota.
DR HOGENOM; CLU_1235988_0_0_1; -.
DR InParanoid; Q7YWN4; -.
DR OMA; MEEAHYD; -.
DR OrthoDB; 1394165at2759; -.
DR PhylomeDB; Q7YWN4; -.
DR PRO; PR:Q7YWN4; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00013603; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR Gene3D; 3.30.505.10; -; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR Pfam; PF00017; SH2; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF55550; SSF55550; 1.
DR PROSITE; PS50001; SH2; 1.
PE 1: Evidence at protein level;
KW Reference proteome; SH2 domain.
FT CHAIN 1..190
FT /note="Protein soem-1"
FT /evidence="ECO:0000305"
FT /id="PRO_0000440172"
FT DOMAIN 96..190
FT /note="SH2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT MUTAGEN 140
FT /note="H->Q: In cas452; suppresses the anterior migration
FT of mutant mig-13 expressing PQR cells, which are
FT descendents of Q neuroblasts. Abolishes interaction with
FT abl-1 in yeast two-hybrid assay."
FT /evidence="ECO:0000269|PubMed:27780040"
SQ SEQUENCE 190 AA; 21216 MW; 846D5E2DF0087DA7 CRC64;
MMMTMAADYG SSEGHYDTPW EFLARPNSVR FSTADVRLST SAAGDAKVSP HGSPSLCSSS
SFVNQLVQIG NSAVDARRKV PRDESKRRRP SDSEIYMEQN MNRVEAEKRL ENRNLGDYLL
RSRGEGSAAL SLRATKGVVH IKIEWNGEKW VIGEGPLFRS ISSAISFYRR HPLPIRGADH
LVLKNQLKPV
