SOGA3_HUMAN
ID SOGA3_HUMAN Reviewed; 947 AA.
AC Q5TF21;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Protein SOGA3;
DE Flags: Precursor;
GN Name=SOGA3; Synonyms=C6orf174;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SOGA family. {ECO:0000305}.
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DR EMBL; AL096711; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001012279.1; NM_001012279.2.
DR AlphaFoldDB; Q5TF21; -.
DR SMR; Q5TF21; -.
DR BioGRID; 132241; 26.
DR IntAct; Q5TF21; 9.
DR MINT; Q5TF21; -.
DR STRING; 9606.ENSP00000434570; -.
DR iPTMnet; Q5TF21; -.
DR PhosphoSitePlus; Q5TF21; -.
DR BioMuta; SOGA3; -.
DR DMDM; 74746351; -.
DR EPD; Q5TF21; -.
DR jPOST; Q5TF21; -.
DR MassIVE; Q5TF21; -.
DR MaxQB; Q5TF21; -.
DR PaxDb; Q5TF21; -.
DR PeptideAtlas; Q5TF21; -.
DR PRIDE; Q5TF21; -.
DR ProteomicsDB; 65069; -.
DR Antibodypedia; 49821; 46 antibodies from 8 providers.
DR DNASU; 387104; -.
DR Ensembl; ENST00000525778.5; ENSP00000434570.1; ENSG00000214338.10.
DR GeneID; 387104; -.
DR KEGG; hsa:387104; -.
DR UCSC; uc003qbd.3; human.
DR CTD; 387104; -.
DR DisGeNET; 387104; -.
DR GeneCards; SOGA3; -.
DR HGNC; HGNC:21494; SOGA3.
DR HPA; ENSG00000214338; Tissue enhanced (brain).
DR neXtProt; NX_Q5TF21; -.
DR OpenTargets; ENSG00000214338; -.
DR OpenTargets; ENSG00000255330; -.
DR PharmGKB; PA134983080; -.
DR VEuPathDB; HostDB:ENSG00000214338; -.
DR eggNOG; KOG4787; Eukaryota.
DR GeneTree; ENSGT00950000182982; -.
DR HOGENOM; CLU_013722_0_0_1; -.
DR InParanoid; Q5TF21; -.
DR OMA; PAICETL; -.
DR OrthoDB; 34629at2759; -.
DR PhylomeDB; Q5TF21; -.
DR TreeFam; TF331853; -.
DR PathwayCommons; Q5TF21; -.
DR SignaLink; Q5TF21; -.
DR BioGRID-ORCS; 387104; 15 hits in 1063 CRISPR screens.
DR ChiTaRS; SOGA3; human.
DR GenomeRNAi; 387104; -.
DR Pharos; Q5TF21; Tdark.
DR PRO; PR:Q5TF21; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q5TF21; protein.
DR Bgee; ENSG00000214338; Expressed in ganglionic eminence and 97 other tissues.
DR ExpressionAtlas; Q5TF21; baseline and differential.
DR Genevisible; Q5TF21; HS.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0010506; P:regulation of autophagy; IEA:InterPro.
DR InterPro; IPR027881; SOGA.
DR Pfam; PF11365; SOGA; 2.
PE 3: Inferred from homology;
KW Coiled coil; Membrane; Phosphoprotein; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..947
FT /note="Protein SOGA3"
FT /id="PRO_0000271352"
FT TRANSMEM 915..935
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 266..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 496..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 743..786
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 342..726
FT /evidence="ECO:0000255"
FT COILED 811..835
FT /evidence="ECO:0000255"
FT COMPBIAS 34..90
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 281..295
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..347
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..368
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 747..786
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 569
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6NZL0"
FT MOD_RES 781
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6NZL0"
SQ SEQUENCE 947 AA; 103199 MW; C920C1D4369F1737 CRC64;
MSQPPIGGAA PATAAASPAA AATEARLHPE GSSRKQQRAQ SPARPRDSSL RQTIAATRSP
VGAGTKLNSV RQQQLQQQQQ QGNKTGSRTG PPASIRGGGG GAEKATPLAP KGAAPGAVQP
VAGAEAAPAA TLAALGGRRP GPPEEPPREL ESVPSKLGEP PPLGEGGGGG GEGGGAGGGS
GEREGGAPQP PPPRGWRGKG VRAQQRGGSG GEGASPSPSS SSAGKTPGTG SRNSGSGVAG
GGSGGGGSYW KEGCLQSELI QFHLKKERAA AAAAAAQMHA KNGGGSSSRS SPVSGPPAVC
ETLAVASASP MAAAAEGPQQ SAEGSASGGG MQAAAPPSSQ PHPQQLQEQE EMQEEMEKLR
EENETLKNEI DELRTEMDEM RDTFFEEDAC QLQEMRHELE RANKNCRILQ YRLRKAERKR
LRYAQTGEID GELLRSLEQD LKVAKDVSVR LHHELENVEE KRTTTEDENE KLRQQLIEVE
IAKQALQNEL EKMKELSLKR RGSKDLPKSE KKAQQTPTEE DNEDLKCQLQ FVKEEAALMR
KKMAKIDKEK DRFEHELQKY RSFYGDLDSP LPKGEAGGPP STREAELKLR LRLVEEEANI
LGRKIVELEV ENRGLKAELD DLRGDDFNGS ANPLMREQSE SLSELRQHLQ LVEDETELLR
RNVADLEEQN KRITAELNKY KYKSGGHDSA RHHDNAKTEA LQEELKAARL QINELSGKVM
QLQYENRVLM SNMQRYDLAS HLGIRGSPRD SDAESDAGKK ESDDDSRPPH RKREGPIGGE
SDSEEVRNIR CLTPTRSFYP APGPWPKSFS DRQQMKDIRS EAERLGKTID RLIADTSTII
TEARIYVANG DLFGLMDEED DGSRIREHEL LYRINAQMKA FRKELQTFID RLEVPKSADD
RGAEEPISVS QMFQPIILLI LILVLFSSLS YTTIFKLVFL FTLFFVL