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SOGA3_HUMAN
ID   SOGA3_HUMAN             Reviewed;         947 AA.
AC   Q5TF21;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=Protein SOGA3;
DE   Flags: Precursor;
GN   Name=SOGA3; Synonyms=C6orf174;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the SOGA family. {ECO:0000305}.
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DR   EMBL; AL096711; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001012279.1; NM_001012279.2.
DR   AlphaFoldDB; Q5TF21; -.
DR   SMR; Q5TF21; -.
DR   BioGRID; 132241; 26.
DR   IntAct; Q5TF21; 9.
DR   MINT; Q5TF21; -.
DR   STRING; 9606.ENSP00000434570; -.
DR   iPTMnet; Q5TF21; -.
DR   PhosphoSitePlus; Q5TF21; -.
DR   BioMuta; SOGA3; -.
DR   DMDM; 74746351; -.
DR   EPD; Q5TF21; -.
DR   jPOST; Q5TF21; -.
DR   MassIVE; Q5TF21; -.
DR   MaxQB; Q5TF21; -.
DR   PaxDb; Q5TF21; -.
DR   PeptideAtlas; Q5TF21; -.
DR   PRIDE; Q5TF21; -.
DR   ProteomicsDB; 65069; -.
DR   Antibodypedia; 49821; 46 antibodies from 8 providers.
DR   DNASU; 387104; -.
DR   Ensembl; ENST00000525778.5; ENSP00000434570.1; ENSG00000214338.10.
DR   GeneID; 387104; -.
DR   KEGG; hsa:387104; -.
DR   UCSC; uc003qbd.3; human.
DR   CTD; 387104; -.
DR   DisGeNET; 387104; -.
DR   GeneCards; SOGA3; -.
DR   HGNC; HGNC:21494; SOGA3.
DR   HPA; ENSG00000214338; Tissue enhanced (brain).
DR   neXtProt; NX_Q5TF21; -.
DR   OpenTargets; ENSG00000214338; -.
DR   OpenTargets; ENSG00000255330; -.
DR   PharmGKB; PA134983080; -.
DR   VEuPathDB; HostDB:ENSG00000214338; -.
DR   eggNOG; KOG4787; Eukaryota.
DR   GeneTree; ENSGT00950000182982; -.
DR   HOGENOM; CLU_013722_0_0_1; -.
DR   InParanoid; Q5TF21; -.
DR   OMA; PAICETL; -.
DR   OrthoDB; 34629at2759; -.
DR   PhylomeDB; Q5TF21; -.
DR   TreeFam; TF331853; -.
DR   PathwayCommons; Q5TF21; -.
DR   SignaLink; Q5TF21; -.
DR   BioGRID-ORCS; 387104; 15 hits in 1063 CRISPR screens.
DR   ChiTaRS; SOGA3; human.
DR   GenomeRNAi; 387104; -.
DR   Pharos; Q5TF21; Tdark.
DR   PRO; PR:Q5TF21; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; Q5TF21; protein.
DR   Bgee; ENSG00000214338; Expressed in ganglionic eminence and 97 other tissues.
DR   ExpressionAtlas; Q5TF21; baseline and differential.
DR   Genevisible; Q5TF21; HS.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0010506; P:regulation of autophagy; IEA:InterPro.
DR   InterPro; IPR027881; SOGA.
DR   Pfam; PF11365; SOGA; 2.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Phosphoprotein; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..947
FT                   /note="Protein SOGA3"
FT                   /id="PRO_0000271352"
FT   TRANSMEM        915..935
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..251
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          266..368
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          496..524
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          743..786
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          342..726
FT                   /evidence="ECO:0000255"
FT   COILED          811..835
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        34..90
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        210..238
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        281..295
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        320..347
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        348..368
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        747..786
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         569
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6NZL0"
FT   MOD_RES         781
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6NZL0"
SQ   SEQUENCE   947 AA;  103199 MW;  C920C1D4369F1737 CRC64;
     MSQPPIGGAA PATAAASPAA AATEARLHPE GSSRKQQRAQ SPARPRDSSL RQTIAATRSP
     VGAGTKLNSV RQQQLQQQQQ QGNKTGSRTG PPASIRGGGG GAEKATPLAP KGAAPGAVQP
     VAGAEAAPAA TLAALGGRRP GPPEEPPREL ESVPSKLGEP PPLGEGGGGG GEGGGAGGGS
     GEREGGAPQP PPPRGWRGKG VRAQQRGGSG GEGASPSPSS SSAGKTPGTG SRNSGSGVAG
     GGSGGGGSYW KEGCLQSELI QFHLKKERAA AAAAAAQMHA KNGGGSSSRS SPVSGPPAVC
     ETLAVASASP MAAAAEGPQQ SAEGSASGGG MQAAAPPSSQ PHPQQLQEQE EMQEEMEKLR
     EENETLKNEI DELRTEMDEM RDTFFEEDAC QLQEMRHELE RANKNCRILQ YRLRKAERKR
     LRYAQTGEID GELLRSLEQD LKVAKDVSVR LHHELENVEE KRTTTEDENE KLRQQLIEVE
     IAKQALQNEL EKMKELSLKR RGSKDLPKSE KKAQQTPTEE DNEDLKCQLQ FVKEEAALMR
     KKMAKIDKEK DRFEHELQKY RSFYGDLDSP LPKGEAGGPP STREAELKLR LRLVEEEANI
     LGRKIVELEV ENRGLKAELD DLRGDDFNGS ANPLMREQSE SLSELRQHLQ LVEDETELLR
     RNVADLEEQN KRITAELNKY KYKSGGHDSA RHHDNAKTEA LQEELKAARL QINELSGKVM
     QLQYENRVLM SNMQRYDLAS HLGIRGSPRD SDAESDAGKK ESDDDSRPPH RKREGPIGGE
     SDSEEVRNIR CLTPTRSFYP APGPWPKSFS DRQQMKDIRS EAERLGKTID RLIADTSTII
     TEARIYVANG DLFGLMDEED DGSRIREHEL LYRINAQMKA FRKELQTFID RLEVPKSADD
     RGAEEPISVS QMFQPIILLI LILVLFSSLS YTTIFKLVFL FTLFFVL
 
 
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