SOGA3_MOUSE
ID SOGA3_MOUSE Reviewed; 945 AA.
AC Q6NZL0; Q8BLM2; Q9CSN3; Q9CU45;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Protein SOGA3;
DE Flags: Precursor;
GN Name=Soga3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-912.
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 205-945.
RC STRAIN=C57BL/6J; TISSUE=Brain cortex, Embryo, and Medulla oblongata;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-567 AND SER-779, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SOGA family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC31794.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC092095; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC153912; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC066079; AAH66079.1; ALT_TERM; mRNA.
DR EMBL; AK012378; BAB28200.1; -; mRNA.
DR EMBL; AK018139; BAB31090.1; -; mRNA.
DR EMBL; AK044134; BAC31794.2; ALT_INIT; mRNA.
DR CCDS; CCDS35875.1; -.
DR RefSeq; NP_080414.2; NM_026138.2.
DR AlphaFoldDB; Q6NZL0; -.
DR SMR; Q6NZL0; -.
DR BioGRID; 212169; 8.
DR IntAct; Q6NZL0; 6.
DR STRING; 10090.ENSMUSP00000090293; -.
DR iPTMnet; Q6NZL0; -.
DR PhosphoSitePlus; Q6NZL0; -.
DR MaxQB; Q6NZL0; -.
DR PaxDb; Q6NZL0; -.
DR PeptideAtlas; Q6NZL0; -.
DR PRIDE; Q6NZL0; -.
DR ProteomicsDB; 261601; -.
DR Ensembl; ENSMUST00000092629; ENSMUSP00000090293; ENSMUSG00000038916.
DR GeneID; 67412; -.
DR KEGG; mmu:67412; -.
DR UCSC; uc007est.1; mouse.
DR CTD; 387104; -.
DR MGI; MGI:1914662; Soga3.
DR VEuPathDB; HostDB:ENSMUSG00000038916; -.
DR eggNOG; KOG4787; Eukaryota.
DR GeneTree; ENSGT00950000182982; -.
DR HOGENOM; CLU_013722_0_0_1; -.
DR InParanoid; Q6NZL0; -.
DR OMA; PAICETL; -.
DR OrthoDB; 34629at2759; -.
DR PhylomeDB; Q6NZL0; -.
DR TreeFam; TF331853; -.
DR BioGRID-ORCS; 67412; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q6NZL0; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q6NZL0; protein.
DR Bgee; ENSMUSG00000038916; Expressed in rostral migratory stream and 110 other tissues.
DR ExpressionAtlas; Q6NZL0; baseline and differential.
DR Genevisible; Q6NZL0; MM.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0010506; P:regulation of autophagy; IEA:InterPro.
DR InterPro; IPR027881; SOGA.
DR Pfam; PF11365; SOGA; 2.
PE 1: Evidence at protein level;
KW Coiled coil; Membrane; Phosphoprotein; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..945
FT /note="Protein SOGA3"
FT /id="PRO_0000271353"
FT TRANSMEM 913..933
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 265..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 307..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 494..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 741..811
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 340..724
FT /evidence="ECO:0000255"
FT COILED 809..833
FT /evidence="ECO:0000255"
FT COMPBIAS 34..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..96
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 318..345
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..366
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 745..787
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 567
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 779
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 719
FT /note="Q -> K (in Ref. 2; BAB31090)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 945 AA; 103480 MW; DBF08203CDAA4182 CRC64;
MSQPPSGGAA PAATSASAAA AATEARMHPE GCSRKQQRAQ SPARPRDNSL RQTAGATRSP
LGVGPKLNSV RQQQLQQQQQ QGNKITGRST SGTGSRGLGG GAEKAVPSIP KGAVPGAVQP
APGAEGSPAA ILASVSFRRS GQPEEAPREI ESGPSKVGEP PPLGGVGGGG EGGGAGGGPG
DREGGAPQPP PPRGWRGKGV RATQRGSSVA EGVSPSPPTA ATSKTPGPGS RNSGSGSTGS
GSGGGGSYWK EGCLQSELIQ FHLKKERAAA AAAAAQMHTK NGGGGSRSSP VAGAPAICEP
LVVPSSSPMA AAAEGPQQSA EGNGSGGAMQ AAAPPSSQPH SQQLQEQEDM QEEMEKLREE
NETLKNEIDE LRTEMDEMRD TFFEEDACQL QEMRHELERA NKNCRILQYR LRKAERKRLR
YAQTGEIDGE LLRSLEQDLK VAKDVSVRLH HELENVEEKR TTTEDENEKL RQQLIEVEIA
KQALQNELEK MKELSLKRRG SKDLPKSEKK AQQTPTEDDN EDLKCQLQFV KEEAALMRKK
MAKIDKEKDR FEHELQKYRS FYGDLDSPLP KGEAGGPPST REAELKLRLR LVEEEANILG
RKIVELEVEN RGLKAELDDL RGEDFNGSSN PLMREQSESL SELRQHLQLV EDETELLRRN
VADLEEQNKR ITAELNKYKY KSSGHDSSRH HDNAKTEALQ EELKAARLQI NELSGKVMQL
QYENRVLMSN MQRYDLASHL GIRGSPRDSD AESDAGKKES DDDSRPPHRK REGPIGGESD
SEEVRNIRSL TPTRSFYPTP GPWPKSFSDR QQMKDIRSEA ERLGKTIDRL IADTSTIITE
ARIYVANGDL FGLMDEEDDG SRIREHELLY RINAQMKAFR KELQTFIDRL EVPKSADDRG
AEEPISVSQM FQPIILLILI LVLFSSLSYT TIFKLVFLFT LFFVL
