ID   SOHB_BUCBP              Reviewed;         349 AA.
AC   Q89AL0;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Putative protease SohB;
DE            EC=3.4.21.-;
GN   Name=sohB; OrderedLocusNames=bbp_263;
OS   Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=224915;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bp;
RX   PubMed=12522265; DOI=10.1073/pnas.0235981100;
RA   van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F.,
RA   Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J.,
RA   Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A.;
RT   "Reductive genome evolution in Buchnera aphidicola.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003).
CC   -!- FUNCTION: Possible protease. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the peptidase S49 family. {ECO:0000305}.
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DR   EMBL; AE016826; AAO26989.1; -; Genomic_DNA.
DR   RefSeq; WP_011091390.1; NC_004545.1.
DR   AlphaFoldDB; Q89AL0; -.
DR   SMR; Q89AL0; -.
DR   STRING; 224915.bbp_263; -.
DR   EnsemblBacteria; AAO26989; AAO26989; bbp_263.
DR   GeneID; 56470805; -.
DR   KEGG; bab:bbp_263; -.
DR   eggNOG; COG0616; Bacteria.
DR   HOGENOM; CLU_070316_0_0_6; -.
DR   OMA; FLYEYGL; -.
DR   OrthoDB; 1318587at2; -.
DR   Proteomes; UP000000601; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd07023; S49_Sppa_N_C; 1.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR002142; Peptidase_S49.
DR   InterPro; IPR013703; Peptidase_S49_N_proteobac.
DR   Pfam; PF01343; Peptidase_S49; 1.
DR   Pfam; PF08496; Peptidase_S49_N; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Hydrolase; Membrane; Protease; Reference proteome;
KW   Serine protease; Transmembrane; Transmembrane helix.
FT   CHAIN           1..349
FT                   /note="Putative protease SohB"
FT                   /id="PRO_0000171446"
FT   TRANSMEM        10..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        188..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        181
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        233
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   349 AA;  40083 MW;  BC82F555A67C7B71 CRC64;
     MHFIYDCSLF LFKIVIVIFF IIFVSSIILK ISRKKNKNFG ILSVSSLNDH YELVKNSIIV
     QLMDKKTKKL WNKKNKMLKR STLLTNNNKL IDKDHNIIVV RAQPTLYVID FKGGIAAHEV
     KSLREEISSI ISVAQKHDEV LLRLESSGGT IHGYGLAAVQ LQRLRSRKIF LTISIDKIAT
     SGGYMMACVA NYIIATPFSI IGSIGVVAQF PNIHKFLKKN NIDVELHTAG VHKRTLTIFG
     ENTPEDRKKF VEELNVAHDL FKKFVKTMRP SLNIEKLSNG ECWFGSIALK KKLVDDINTS
     DDFIISRIRK FNILHVKFKY NESIIKALFY KKLKTINNLI YKYLNNKLF