ID   SOJ_BACSU               Reviewed;         253 AA.
AC   P37522;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=Sporulation initiation inhibitor protein Soj;
DE            EC=3.6.-.-;
GN   Name=soj; Synonyms=orf253; OrderedLocusNames=BSU40970;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / CRK2000;
RX   PubMed=1552862; DOI=10.1111/j.1365-2958.1992.tb01510.x;
RA   Ogasawara N., Yoshikawa H.;
RT   "Genes and their organization in the replication origin region of the
RT   bacterial chromosome.";
RL   Mol. Microbiol. 6:629-634(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=7584024; DOI=10.1093/dnares/1.1.1;
RA   Ogasawara N., Nakai S., Yoshikawa H.;
RT   "Systematic sequencing of the 180 kilobase region of the Bacillus subtilis
RT   chromosome containing the replication origin.";
RL   DNA Res. 1:1-14(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [4]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=168 / JH642;
RX   PubMed=8071208; DOI=10.1128/jb.176.17.5320-5329.1994;
RA   Ireton K., Gunther N.W. IV, Grossman A.D.;
RT   "spo0J is required for normal chromosome segregation as well as the
RT   initiation of sporulation in Bacillus subtilis.";
RL   J. Bacteriol. 176:5320-5329(1994).
CC   -!- FUNCTION: Inhibits the initiation of sporulation, Spo0J antagonizes
CC       this inhibition. Soj ultimately inhibits the activation
CC       (phosphorylation) of Spo0A. {ECO:0000269|PubMed:8071208}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC   -!- INTERACTION:
CC       P37522; P05648: dnaA; NbExp=2; IntAct=EBI-2014674, EBI-2014722;
CC   -!- DISRUPTION PHENOTYPE: Not required for sporulation or for chromosome
CC       partioning. {ECO:0000269|PubMed:8071208}.
CC   -!- SIMILARITY: Belongs to the ParA family. {ECO:0000305}.
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DR   EMBL; X62539; CAA44408.1; -; Genomic_DNA.
DR   EMBL; D26185; BAA05227.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB16134.1; -; Genomic_DNA.
DR   PIR; I40444; I40444.
DR   RefSeq; NP_391977.1; NC_000964.3.
DR   RefSeq; WP_003219244.1; NZ_JNCM01000034.1.
DR   AlphaFoldDB; P37522; -.
DR   SMR; P37522; -.
DR   IntAct; P37522; 2.
DR   STRING; 224308.BSU40970; -.
DR   PaxDb; P37522; -.
DR   PRIDE; P37522; -.
DR   EnsemblBacteria; CAB16134; CAB16134; BSU_40970.
DR   GeneID; 64305884; -.
DR   GeneID; 937928; -.
DR   KEGG; bsu:BSU40970; -.
DR   PATRIC; fig|224308.179.peg.4439; -.
DR   eggNOG; COG1192; Bacteria.
DR   InParanoid; P37522; -.
DR   OMA; VQCEYFA; -.
DR   PhylomeDB; P37522; -.
DR   BioCyc; BSUB:BSU40970-MON; -.
DR   PRO; PR:P37522; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0042174; P:negative regulation of sporulation resulting in formation of a cellular spore; IGI:CACAO.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR025669; AAA_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF13614; AAA_31; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Hydrolase; Nucleotide-binding; Reference proteome;
KW   Sporulation.
FT   CHAIN           1..253
FT                   /note="Sporulation initiation inhibitor protein Soj"
FT                   /id="PRO_0000201981"
FT   BINDING         10..17
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   253 AA;  27543 MW;  6BEBB5590EB92F78 CRC64;
     MGKIIAITNQ KGGVGKTTTS VNLGACLAYI GKRVLLVDID PQGNATSGLG IEKADVEQCV
     YDILVDDADV IDIIKATTVE NLDVIPATIQ LAGAEIELVP TISREVRLKR ALEAVKQNYD
     YIIIDCPPSL GLLTINALTA SDSVVIPVQC EYYALEGLSQ LLNTVRLVQK HLNTDLMIEG
     VLLTMLDART NLGIQVIEEV KKYFRDKVYK TVIPRNVRLS EAPSHGKPII LYDPRSRGAE
     VYLDLAKEVA ANG