SOK1_PHYPA
ID SOK1_PHYPA Reviewed; 701 AA.
AC A0A2K1JJ00;
DT 07-APR-2021, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2018, sequence version 1.
DT 03-AUG-2022, entry version 18.
DE RecName: Full=Protein SOSEKI 1 {ECO:0000303|PubMed:32004461};
DE Short=PpSOK1 {ECO:0000303|PubMed:32004461};
GN Name=SOK1 {ECO:0000303|PubMed:32004461};
GN ORFNames=PHYPA_018923 {ECO:0000312|EMBL:PNR41520.1};
OS Physcomitrium patens (Spreading-leaved earth moss) (Physcomitrella patens).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Bryophyta;
OC Bryophytina; Bryopsida; Funariidae; Funariales; Funariaceae; Physcomitrium.
OX NCBI_TaxID=3218;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Gransden 2004;
RX PubMed=18079367; DOI=10.1126/science.1150646;
RA Rensing S.A., Lang D., Zimmer A.D., Terry A., Salamov A., Shapiro H.,
RA Nishiyama T., Perroud P.-F., Lindquist E.A., Kamisugi Y., Tanahashi T.,
RA Sakakibara K., Fujita T., Oishi K., Shin-I T., Kuroki Y., Toyoda A.,
RA Suzuki Y., Hashimoto S.-I., Yamaguchi K., Sugano S., Kohara Y.,
RA Fujiyama A., Anterola A., Aoki S., Ashton N., Barbazuk W.B., Barker E.,
RA Bennetzen J.L., Blankenship R., Cho S.H., Dutcher S.K., Estelle M.,
RA Fawcett J.A., Gundlach H., Hanada K., Heyl A., Hicks K.A., Hughes J.,
RA Lohr M., Mayer K., Melkozernov A., Murata T., Nelson D.R., Pils B.,
RA Prigge M., Reiss B., Renner T., Rombauts S., Rushton P.J., Sanderfoot A.,
RA Schween G., Shiu S.-H., Stueber K., Theodoulou F.L., Tu H., Van de Peer Y.,
RA Verrier P.J., Waters E., Wood A., Yang L., Cove D., Cuming A.C., Hasebe M.,
RA Lucas S., Mishler B.D., Reski R., Grigoriev I.V., Quatrano R.S.,
RA Boore J.L.;
RT "The Physcomitrella genome reveals evolutionary insights into the conquest
RT of land by plants.";
RL Science 319:64-69(2008).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Gransden 2004;
RX PubMed=29237241; DOI=10.1111/tpj.13801;
RA Lang D., Ullrich K.K., Murat F., Fuchs J., Jenkins J., Haas F.B.,
RA Piednoel M., Gundlach H., Van Bel M., Meyberg R., Vives C., Morata J.,
RA Symeonidi A., Hiss M., Muchero W., Kamisugi Y., Saleh O., Blanc G.,
RA Decker E.L., van Gessel N., Grimwood J., Hayes R.D., Graham S.W.,
RA Gunter L.E., McDaniel S.F., Hoernstein S.N.W., Larsson A., Li F.W.,
RA Perroud P.F., Phillips J., Ranjan P., Rokshar D.S., Rothfels C.J.,
RA Schneider L., Shu S., Stevenson D.W., Thummler F., Tillich M.,
RA Villarreal Aguilar J.C., Widiez T., Wong G.K., Wymore A., Zhang Y.,
RA Zimmer A.D., Quatrano R.S., Mayer K.F.X., Goodstein D., Casacuberta J.M.,
RA Vandepoele K., Reski R., Cuming A.C., Tuskan G.A., Maumus F., Salse J.,
RA Schmutz J., Rensing S.A.;
RT "The Physcomitrella patens chromosome-scale assembly reveals moss genome
RT structure and evolution.";
RL Plant J. 93:515-533(2018).
RN [3]
RP SUBUNIT, AND GENE FAMILY.
RX PubMed=32004461; DOI=10.1016/j.cell.2020.01.011;
RA van Dop M., Fiedler M., Mutte S., de Keijzer J., Olijslager L.,
RA Albrecht C., Liao C.Y., Janson M.E., Bienz M., Weijers D.;
RT "DIX domain polymerization drives assembly of plant cell polarity
RT complexes.";
RL Cell 180:427.e12-439.e12(2020).
CC -!- FUNCTION: SOSEKI proteins locally interpret global polarity cues and
CC can influence cell division orientation to coordinate cell polarization
CC relative to body axes. {ECO:0000250|UniProtKB:Q9SYJ8}.
CC -!- SUBUNIT: Homodimer (By similarity). Forms long polymer filaments with
CC other SOKs proteins polymers crucial for polar localization and
CC biological activity (PubMed:32004461). {ECO:0000250|UniProtKB:Q9SYJ8,
CC ECO:0000269|PubMed:32004461}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9SYJ8};
CC Peripheral membrane protein {ECO:0000250|UniProtKB:Q9SYJ8}; Cytoplasmic
CC side {ECO:0000250|UniProtKB:Q9SYJ8}.
CC -!- DOMAIN: The DIX-like oligomerization domain is required for
CC polymerization, edge localization and biological activity.
CC {ECO:0000250|UniProtKB:Q9SYJ8}.
CC -!- MISCELLANEOUS: 'Soseki' means cornerstone in Japanese. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SOSEKI family. {ECO:0000305}.
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DR EMBL; ABEU02000014; PNR41520.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2K1JJ00; -.
DR SMR; A0A2K1JJ00; -.
DR STRING; 3218.PP1S69_3V6.1; -.
DR EnsemblPlants; Pp3c14_23220V3.1; Pp3c14_23220V3.1; Pp3c14_23220.
DR EnsemblPlants; Pp3c14_23220V3.2; Pp3c14_23220V3.2; Pp3c14_23220.
DR Gramene; Pp3c14_23220V3.1; Pp3c14_23220V3.1; Pp3c14_23220.
DR Gramene; Pp3c14_23220V3.2; Pp3c14_23220V3.2; Pp3c14_23220.
DR OrthoDB; 543876at2759; -.
DR Proteomes; UP000006727; Chromosome 14.
DR GO; GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; ISS:UniProtKB.
DR GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:1905392; P:plant organ morphogenesis; ISS:UniProtKB.
DR GO; GO:0051258; P:protein polymerization; IDA:UniProtKB.
DR GO; GO:0051302; P:regulation of cell division; ISS:UniProtKB.
DR GO; GO:0090708; P:specification of plant organ axis polarity; ISS:UniProtKB.
DR InterPro; IPR010369; SOK.
DR PANTHER; PTHR31083; PTHR31083; 1.
DR Pfam; PF06136; SOK2_plant; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Cell membrane; Developmental protein; Membrane;
KW Reference proteome.
FT CHAIN 1..701
FT /note="Protein SOSEKI 1"
FT /id="PRO_0000452145"
FT REGION 8..101
FT /note="DIX-like oligomerization domain"
FT /evidence="ECO:0000250|UniProtKB:Q9SYJ8"
FT REGION 238..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 300..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 366..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 538..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..260
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 554..568
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 701 AA; 77662 MW; FB4668822ABC15B4 CRC64;
MAFEENFLSA QVLYQLSWNG KLEHPHIIDV EYASDQGGLR LRDVKERLTR LRGHGINDSF
SWSYKRTYSK TFIWNDLSDD DVIHPLCGSG EYVLRASELI DTNERKSCDV HSRHSNKSMQ
SSPTMLLDNV TSKQDTIIGD VHFGALESGE NRRIGDKLNC LVRNSGANLE EVKSLRGVSA
VISQSLPTLY ADQEIMDVEK SDFCLSSSDT EISPRPKMTV DSIKPVKDVN LVVMTKSSTV
HGVHTPPSPS LKSSTELPFS PGGTKRLWEK EIRKSLFRTR NSSNVNSVST EDFTAVHMEL
PPNTHSTHED NSFWRDSRSK SPSPSSLNEL KEVQIDKEEV EQSTSQLIRL LWARWTGGSS
KGKRIPYNTC EGASTKIPES KHNSPYRTKS PYKEIRSTHV EGSHQETRQS LAVQSKARVS
LEIKEILPPE ECMHYPSPMT VQNVTEVASP HAQTDGGGDV CTIKTIVSEQ ASQPYPEPRD
LRTDQGILSE KTPGLHIAVL EGLTSDAPSG PAEAEVDTPL PAVARAKTGN TLSKLKTIAS
SKPLPPGFHK GTNDTKPVQI TPRRTPRNSI PLASPPLVRS FSRDAVRGFS SLAAISLCPD
KDSVACTPSP EKTIVKKRIN YSAREEMPLV PGLTTLDWEK ALQEATTDCL PPPNFSDILQ
ECSICRRTFK PDSLQVHMRG CHPPQYARAF SARASPHVVR C
