SOK4_PHYPA
ID SOK4_PHYPA Reviewed; 390 AA.
AC A9RNY0;
DT 07-APR-2021, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 1.
DT 03-AUG-2022, entry version 54.
DE RecName: Full=Protein SOSEKI 4 {ECO:0000303|PubMed:32004461};
DE Short=PpSOK4 {ECO:0000303|PubMed:32004461};
GN Name=SOK4 {ECO:0000303|PubMed:32004461};
GN ORFNames=PHYPA_022993 {ECO:0000312|EMBL:PNR35094.1},
GN PHYPADRAFT_160198 {ECO:0000312|EMBL:EDQ79421.1};
OS Physcomitrium patens (Spreading-leaved earth moss) (Physcomitrella patens).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Bryophyta;
OC Bryophytina; Bryopsida; Funariidae; Funariales; Funariaceae; Physcomitrium.
OX NCBI_TaxID=3218;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Gransden 2004;
RX PubMed=18079367; DOI=10.1126/science.1150646;
RA Rensing S.A., Lang D., Zimmer A.D., Terry A., Salamov A., Shapiro H.,
RA Nishiyama T., Perroud P.-F., Lindquist E.A., Kamisugi Y., Tanahashi T.,
RA Sakakibara K., Fujita T., Oishi K., Shin-I T., Kuroki Y., Toyoda A.,
RA Suzuki Y., Hashimoto S.-I., Yamaguchi K., Sugano S., Kohara Y.,
RA Fujiyama A., Anterola A., Aoki S., Ashton N., Barbazuk W.B., Barker E.,
RA Bennetzen J.L., Blankenship R., Cho S.H., Dutcher S.K., Estelle M.,
RA Fawcett J.A., Gundlach H., Hanada K., Heyl A., Hicks K.A., Hughes J.,
RA Lohr M., Mayer K., Melkozernov A., Murata T., Nelson D.R., Pils B.,
RA Prigge M., Reiss B., Renner T., Rombauts S., Rushton P.J., Sanderfoot A.,
RA Schween G., Shiu S.-H., Stueber K., Theodoulou F.L., Tu H., Van de Peer Y.,
RA Verrier P.J., Waters E., Wood A., Yang L., Cove D., Cuming A.C., Hasebe M.,
RA Lucas S., Mishler B.D., Reski R., Grigoriev I.V., Quatrano R.S.,
RA Boore J.L.;
RT "The Physcomitrella genome reveals evolutionary insights into the conquest
RT of land by plants.";
RL Science 319:64-69(2008).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Gransden 2004;
RX PubMed=29237241; DOI=10.1111/tpj.13801;
RA Lang D., Ullrich K.K., Murat F., Fuchs J., Jenkins J., Haas F.B.,
RA Piednoel M., Gundlach H., Van Bel M., Meyberg R., Vives C., Morata J.,
RA Symeonidi A., Hiss M., Muchero W., Kamisugi Y., Saleh O., Blanc G.,
RA Decker E.L., van Gessel N., Grimwood J., Hayes R.D., Graham S.W.,
RA Gunter L.E., McDaniel S.F., Hoernstein S.N.W., Larsson A., Li F.W.,
RA Perroud P.F., Phillips J., Ranjan P., Rokshar D.S., Rothfels C.J.,
RA Schneider L., Shu S., Stevenson D.W., Thummler F., Tillich M.,
RA Villarreal Aguilar J.C., Widiez T., Wong G.K., Wymore A., Zhang Y.,
RA Zimmer A.D., Quatrano R.S., Mayer K.F.X., Goodstein D., Casacuberta J.M.,
RA Vandepoele K., Reski R., Cuming A.C., Tuskan G.A., Maumus F., Salse J.,
RA Schmutz J., Rensing S.A.;
RT "The Physcomitrella patens chromosome-scale assembly reveals moss genome
RT structure and evolution.";
RL Plant J. 93:515-533(2018).
RN [3]
RP SUBUNIT, AND GENE FAMILY.
RX PubMed=32004461; DOI=10.1016/j.cell.2020.01.011;
RA van Dop M., Fiedler M., Mutte S., de Keijzer J., Olijslager L.,
RA Albrecht C., Liao C.Y., Janson M.E., Bienz M., Weijers D.;
RT "DIX domain polymerization drives assembly of plant cell polarity
RT complexes.";
RL Cell 180:427.e12-439.e12(2020).
CC -!- FUNCTION: SOSEKI proteins locally interpret global polarity cues and
CC can influence cell division orientation to coordinate cell polarization
CC relative to body axes. {ECO:0000250|UniProtKB:Q9SYJ8}.
CC -!- SUBUNIT: Homodimer (By similarity). Forms long polymer filaments with
CC other SOKs proteins polymers crucial for polar localization and
CC biological activity (PubMed:32004461). {ECO:0000250|UniProtKB:Q9SYJ8,
CC ECO:0000269|PubMed:32004461}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9SYJ8};
CC Peripheral membrane protein {ECO:0000250|UniProtKB:Q9SYJ8}; Cytoplasmic
CC side {ECO:0000250|UniProtKB:Q9SYJ8}.
CC -!- DOMAIN: The DIX-like oligomerization domain is required for
CC polymerization, edge localization and biological activity.
CC {ECO:0000250|UniProtKB:Q9SYJ8}.
CC -!- MISCELLANEOUS: 'Soseki' means cornerstone in Japanese. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SOSEKI family. {ECO:0000305}.
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DR EMBL; DS544908; EDQ79421.1; -; Genomic_DNA.
DR EMBL; ABEU02000018; PNR35094.1; -; Genomic_DNA.
DR RefSeq; XP_001755748.1; XM_001755696.1.
DR AlphaFoldDB; A9RNY0; -.
DR SMR; A9RNY0; -.
DR STRING; 3218.PP1S19_321V6.1; -.
DR EnsemblPlants; Pp3c18_11140V3.1; Pp3c18_11140V3.1; Pp3c18_11140.
DR EnsemblPlants; Pp3c18_11140V3.2; Pp3c18_11140V3.2; Pp3c18_11140.
DR EnsemblPlants; Pp3c18_11140V3.3; Pp3c18_11140V3.3; Pp3c18_11140.
DR Gramene; Pp3c18_11140V3.1; Pp3c18_11140V3.1; Pp3c18_11140.
DR Gramene; Pp3c18_11140V3.2; Pp3c18_11140V3.2; Pp3c18_11140.
DR Gramene; Pp3c18_11140V3.3; Pp3c18_11140V3.3; Pp3c18_11140.
DR eggNOG; ENOG502QVHU; Eukaryota.
DR HOGENOM; CLU_708616_0_0_1; -.
DR InParanoid; A9RNY0; -.
DR Proteomes; UP000006727; Chromosome 18.
DR GO; GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; ISS:UniProtKB.
DR GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:1905392; P:plant organ morphogenesis; ISS:UniProtKB.
DR GO; GO:0051258; P:protein polymerization; IDA:UniProtKB.
DR GO; GO:0051302; P:regulation of cell division; ISS:UniProtKB.
DR GO; GO:0090708; P:specification of plant organ axis polarity; ISS:UniProtKB.
DR InterPro; IPR010369; SOK.
DR PANTHER; PTHR31083; PTHR31083; 1.
DR Pfam; PF06136; SOK2_plant; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Cell membrane; Developmental protein; Membrane;
KW Reference proteome.
FT CHAIN 1..390
FT /note="Protein SOSEKI 4"
FT /id="PRO_0000452148"
FT REGION 22..115
FT /note="DIX-like oligomerization domain"
FT /evidence="ECO:0000250|UniProtKB:Q9SYJ8"
FT REGION 210..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 291..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..229
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..320
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 390 AA; 44293 MW; B1308A0387DA82D6 CRC64;
MPSLRTERRS FGMETPRHSS FRMAEVLYVL SCGGQLEHPH MINVQYPVHQ PGPTLRDVKT
RLIALRGRGM PDSFSWSYKR NYKDTFIWCD LFDDNFILPL SESGEYALKA TKRFDASQVK
YLRPPRRSEN LEAEGDVSMV VKKGLVLISD TGSVTSNRTM ELNKQLMNSL SHSRSAAAVR
NNEHSDVSSS DTHYSYEDVI ERKDYPARCK SNSGATKRGK ASVTPKQCHP SSRPAYWEFS
PQGNRTGRED SLMTIGLTKH VVEENEGPTT PRAPARRRTW KKEIDKITIF RESNNSESSD
DEQPSVQAET HVSKLSKSGG SYSAAPEDLF LYILRKATRL GSFKPRVCTE VDVVDSTQSK
TKMLFRSKTK DEVNRLLYHS PLKQDQSIKK
