SOLD1_BOVIN
ID SOLD1_BOVIN Reviewed; 100 AA.
AC P83107; A6QQ03; B5AFL1; C4T8T2;
DT 27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2001, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Secreted protein of Ly-6 domain 1 {ECO:0000303|PubMed:19503832};
DE AltName: Full=Protein BOP1 {ECO:0000303|PubMed:11840564};
DE Flags: Precursor;
GN Name=SOLD1 {ECO:0000303|PubMed:19503832};
GN Synonyms=BOP1 {ECO:0000303|PubMed:11840564};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1] {ECO:0000312|EMBL:BAH70331.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, AND GLYCOSYLATION.
RC TISSUE=Placenta {ECO:0000312|EMBL:BAH70331.1};
RX PubMed=19503832; DOI=10.1371/journal.pone.0005814;
RA Ushizawa K., Takahashi T., Hosoe M., Kizaki K., Hashizume K.;
RT "Characterization and expression analysis of SOLD1, a novel member of the
RT retrotransposon-derived Ly-6 superfamily, in bovine placental villi.";
RL PLoS ONE 4:e5814-e5814(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RX PubMed=11282978; DOI=10.1101/gr.170101;
RA Smith T.P.L., Grosse W.M., Freking B.A., Roberts A.J., Stone R.T.,
RA Casas E., Wray J.E., White J., Cho J., Fahrenkrug S.C., Bennett G.L.,
RA Heaton M.P., Laegreid W.W., Rohrer G.A., Chitko-McKown C.G., Pertea G.,
RA Holt I., Karamycheva S., Liang F., Quackenbush J., Keele J.W.;
RT "Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries
RT and construction of a gene index for cattle.";
RL Genome Res. 11:626-630(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=17488528; DOI=10.1186/1471-2164-8-113;
RA Kumar C.G., Larson J.H., Band M.R., Lewin H.A.;
RT "Discovery and characterization of 91 novel transcripts expressed in cattle
RT placenta.";
RL BMC Genomics 8:113-113(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Placenta;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP IDENTIFICATION.
RX PubMed=11840564;
RX DOI=10.1002/1615-9861(200202)2:2<187::aid-prot187>3.0.co;2-a;
RA Southan C., Cutler P., Birrell H., Connell J., Fantom K.G.M., Sims M.,
RA Shaikh N., Schneider K.;
RT "The characterisation of novel secreted Ly-6 proteins from rat urine by the
RT combined use of two-dimensional gel electrophoresis, microbore high
RT performance liquid chromatography and expressed sequence tag data.";
RL Proteomics 2:187-196(2002).
RN [6] {ECO:0000305}
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=23759217; DOI=10.1016/j.placenta.2013.05.004;
RA Awad M., Kizaki K., Takahashi T., Hashizume K.;
RT "Dynamic expression of SOLD1 in bovine uteroplacental tissues during
RT gestation.";
RL Placenta 34:635-641(2013).
CC -!- FUNCTION: Binds specifically to type I collagen.
CC {ECO:0000269|PubMed:19503832}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19503832}.
CC Note=Probably secreted from the basolateral region of the cell near the
CC extracellular matrix. {ECO:0000269|PubMed:19503832}.
CC -!- TISSUE SPECIFICITY: Expressed in placenta, where it is detected in both
CC fetal tissues (cotyledon and intercotyledon) and maternal tissues
CC (caruncle and intercaruncular endometrium) (at protein level)
CC (PubMed:19503832, PubMed:23759217). Expressed in the mesenchyme area of
CC villi in the cotyledon (at protein level) (PubMed:19503832,
CC PubMed:23759217). In endometrium, expressed in the luminal epithelium
CC and weakly in the subluminal stroma (at protein level)
CC (PubMed:23759217). Detected in trophoblast mononucleate cells (TMCs)
CC (at protein level) (PubMed:19503832). Also detected in trophoblast
CC binucleate cells (BNCs) (PubMed:23759217). Overall, expression is
CC strongest in fetal tissue and lower in maternal tissue
CC (PubMed:19503832, PubMed:23759217). Not detected in other tissues
CC tested (PubMed:19503832). {ECO:0000269|PubMed:19503832,
CC ECO:0000269|PubMed:23759217}.
CC -!- DEVELOPMENTAL STAGE: Detected in the placenta from day 11 of gestation
CC onwards (PubMed:19503832, PubMed:23759217). Expressed in the conceptus
CC at the pre- and peri-implantation stages (gestational days 11-21)
CC (PubMed:19503832). Expressed in the extra-embryonic membrane at the
CC post-implantation stage (gestational days 27-33), although expression
CC appears to decline temporarily at gestational day 27 (PubMed:19503832).
CC Expressed in cotyledon from early to late gestation (gestational days
CC 60 to 250), with highest expression levels at gestational day 60 and
CC declining expression thereafter (PubMed:19503832, PubMed:23759217).
CC Also expressed in intercotyledon from gestational day 60 onwards,
CC reaching maximum expression levels during late gestation
CC (PubMed:19503832, PubMed:23759217). Expressed in caruncle from early to
CC late gestation, reaching maximum expression at the late gestation stage
CC (PubMed:23759217). Has low expression in intercarunclar tissue during
CC early gestation, but expression levels increase by mid gestation and
CC remain high during late gestation (PubMed:23759217).
CC {ECO:0000269|PubMed:19503832, ECO:0000269|PubMed:23759217}.
CC -!- PTM: Glycosylated. {ECO:0000269|PubMed:19503832}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB297495; BAH70331.1; -; mRNA.
DR EMBL; BE683716; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; EU846101; ACF60485.1; -; mRNA.
DR EMBL; BC149580; AAI49581.1; -; mRNA.
DR RefSeq; NP_001098948.1; NM_001105478.1.
DR AlphaFoldDB; P83107; -.
DR SMR; P83107; -.
DR STRING; 9913.ENSBTAP00000056241; -.
DR PaxDb; P83107; -.
DR Ensembl; ENSBTAT00000067325; ENSBTAP00000061582; ENSBTAG00000052794.
DR GeneID; 100125878; -.
DR KEGG; bta:100125878; -.
DR CTD; 100125878; -.
DR VEuPathDB; HostDB:ENSBTAG00000052794; -.
DR eggNOG; ENOG502TDW1; Eukaryota.
DR GeneTree; ENSGT00940000163158; -.
DR InParanoid; P83107; -.
DR OMA; GFQECSH; -.
DR OrthoDB; 1575740at2759; -.
DR Proteomes; UP000009136; Chromosome 29.
DR Bgee; ENSBTAG00000052794; Expressed in conceptus and 75 other tissues.
DR ExpressionAtlas; P83107; baseline and differential.
DR GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR GO; GO:0005518; F:collagen binding; IDA:UniProtKB.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..100
FT /note="Secreted protein of Ly-6 domain 1"
FT /id="PRO_0000036172"
FT DOMAIN 23..100
FT /note="UPAR/Ly6"
FT /evidence="ECO:0000305"
FT CARBOHYD 60
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 25..52
FT /evidence="ECO:0000255"
FT DISULFID 28..37
FT /evidence="ECO:0000255"
FT DISULFID 44..70
FT /evidence="ECO:0000255"
FT DISULFID 74..90
FT /evidence="ECO:0000255"
FT DISULFID 91..97
FT /evidence="ECO:0000255"
SQ SEQUENCE 100 AA; 10951 MW; 7EB2F94FAA7C9CF8 CRC64;
MAKCLLLLLL VVLSSLLGLP QALECFQCNR VNASGVCETG GSTCQTQGSQ QCFLRRIFEN
GTLSYGHQGC SQLCIPMKLF NPSVIVEYKC CHDSPLCNKF
