ID   SOLH2_RAT               Reviewed;         462 AA.
AC   Q3MHT3;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2;
GN   Name=Sohlh2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Probable transcription factor, which may be involved in
CC       spermatogenesis and oogenesis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
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DR   EMBL; BC104697; AAI04698.1; -; mRNA.
DR   RefSeq; NP_001030133.1; NM_001034961.1.
DR   AlphaFoldDB; Q3MHT3; -.
DR   SMR; Q3MHT3; -.
DR   STRING; 10116.ENSRNOP00000049772; -.
DR   PaxDb; Q3MHT3; -.
DR   PRIDE; Q3MHT3; -.
DR   Ensembl; ENSRNOT00000044424; ENSRNOP00000049772; ENSRNOG00000038091.
DR   GeneID; 619575; -.
DR   KEGG; rno:619575; -.
DR   UCSC; RGD:1589577; rat.
DR   CTD; 54937; -.
DR   RGD; 1589577; Sohlh2.
DR   eggNOG; ENOG502S71C; Eukaryota.
DR   GeneTree; ENSGT00390000016050; -.
DR   HOGENOM; CLU_056118_0_0_1; -.
DR   InParanoid; Q3MHT3; -.
DR   OMA; NIVVKYW; -.
DR   OrthoDB; 643083at2759; -.
DR   PhylomeDB; Q3MHT3; -.
DR   TreeFam; TF336841; -.
DR   PRO; PR:Q3MHT3; -.
DR   Proteomes; UP000002494; Chromosome 2.
DR   Bgee; ENSRNOG00000038091; Expressed in testis.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:RGD.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR   GO; GO:0046982; F:protein heterodimerization activity; ISO:RGD.
DR   GO; GO:0042803; F:protein homodimerization activity; ISO:RGD.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; ISO:RGD.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR   GO; GO:0030154; P:cell differentiation; ISO:RGD.
DR   GO; GO:0009994; P:oocyte differentiation; ISO:RGD.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR   GO; GO:0001545; P:primary ovarian follicle growth; ISO:RGD.
DR   GO; GO:0010468; P:regulation of gene expression; ISO:RGD.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0007283; P:spermatogenesis; ISO:RGD.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR032669; SOHLH2.
DR   PANTHER; PTHR16223:SF16; PTHR16223:SF16; 1.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; DNA-binding; Nucleus; Oogenesis;
KW   Reference proteome; Spermatogenesis; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..462
FT                   /note="Spermatogenesis- and oogenesis-specific basic helix-
FT                   loop-helix-containing protein 2"
FT                   /id="PRO_0000315702"
FT   DOMAIN          200..251
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          422..462
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   462 AA;  50669 MW;  589BADC7ED81958F CRC64;
     MADRISTGEL GRRPGQGRVD LLLVGDATRY FLAGSVQKFF SSTAQITLTI SNVKKVAALL
     AANSFDIIFL KVTSTLTAEE QEAVRLIRSG KKKNTHLLFA FVIPEKLRGY ISDYGADISF
     NEPLTLEKVN TVINYWKTYF TNTDMGNTEL PPECRLYFQT SCSELGGHFP TDLFLCSELL
     NNDTGLGLKA PLSSPERNKK ASFLHSSKEK LRRERIKFCC EQLRTLLPYV KGRKSDVASV
     IEATVDYVKQ VRESLSPAIM AQITESLQSN KRFSKRQMPI ELFLPCTATS QRGDAMLTSA
     FSPVQEIQLL ADQGLNVYSM PAAGGPLEEA VRGQPGSVSE DLYKTRVPST TLSLNSFHAV
     RYCSGPVSPH EAAARTNQNI SIYLPPTGPS VSSFTPQHCN AMLCPTRPAS SSCLCTSGHE
     LPASSRTASS SIFRGFRESD SGHQASQQPT GPSLQPQDSS YF