ID   SOM2_MACMU              Reviewed;         217 AA.
AC   Q07370; Q28494;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Growth hormone variant;
DE            Short=GH-V;
DE   AltName: Full=Growth hormone 2;
DE   AltName: Full=Placenta-specific growth hormone;
DE   Flags: Precursor;
GN   Name=GH2;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RA   Golos T.G.;
RL   Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Placenta;
RX   PubMed=8404617; DOI=10.1210/endo.133.4.8404617;
RA   Golos T.G., Durning M., Fisher J.M., Fowler P.D.;
RT   "Cloning of four growth hormone/chorionic somatomammotropin-related
RT   complementary deoxyribonucleic acids differentially expressed during
RT   pregnancy in the rhesus monkey placenta.";
RL   Endocrinology 133:1744-1752(1993).
CC   -!- FUNCTION: Plays an important role in growth control. Its major role in
CC       stimulating body growth is to stimulate the liver and other tissues to
CC       secrete IGF-1. It stimulates both the differentiation and proliferation
CC       of myoblasts. It also stimulates amino acid uptake and protein
CC       synthesis in muscle and other tissues.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in the placenta.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; U02293; AAA03391.1; -; Unassigned_DNA.
DR   EMBL; L16555; AAA20180.1; -; mRNA.
DR   PIR; I67411; I67411.
DR   RefSeq; NP_001036204.1; NM_001042739.1.
DR   AlphaFoldDB; Q07370; -.
DR   SMR; Q07370; -.
DR   STRING; 9544.ENSMMUP00000034201; -.
DR   GeneID; 700885; -.
DR   KEGG; mcc:700885; -.
DR   CTD; 102973055; -.
DR   eggNOG; ENOG502R5GJ; Eukaryota.
DR   InParanoid; Q07370; -.
DR   OrthoDB; 1190548at2759; -.
DR   Proteomes; UP000006718; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR   GO; GO:0005131; F:growth hormone receptor binding; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0048513; P:animal organ development; IBA:GO_Central.
DR   GO; GO:0060396; P:growth hormone receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0045927; P:positive regulation of growth; IBA:GO_Central.
DR   GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR   GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IBA:GO_Central.
DR   GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Phosphoprotein; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000250"
FT   CHAIN           27..217
FT                   /note="Growth hormone variant"
FT                   /id="PRO_0000033062"
FT   MOD_RES         132
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01241"
FT   MOD_RES         176
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01241"
FT   DISULFID        79..191
FT                   /evidence="ECO:0000250"
FT   DISULFID        208..215
FT                   /evidence="ECO:0000250"
FT   CONFLICT        57
FT                   /note="L -> F (in Ref. 2; AAA20180)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        152
FT                   /note="E -> G (in Ref. 2; AAA20180)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   217 AA;  25221 MW;  8DB116CBC24EA090 CRC64;
     MAAGSWTCLI LAIALLCLPW LQEGSAFPTI PLSWLFNTAV FRAHHLHKLA FDTYPKLEEA
     YIPKEQKYSF LRNPQTSLCF SESIPTPSNK EETQQKSNLE LLHISLLLIQ SWLEPVQFLR
     SVFANHLVHT NSNFDIYLYL KKLEEGIQTL MERLEDGSPR TGQIFKETYS KYDTNSHNDD
     TLLKNYRLLY CFRKDMNKVE TFLRTVRCRA VEGSCGF