ID   SOM2_PANTR              Reviewed;         217 AA.
AC   P58757;
DT   27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT   27-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Growth hormone variant;
DE            Short=GH-V;
DE   AltName: Full=Growth hormone 2;
DE   AltName: Full=Placenta-specific growth hormone;
DE   Flags: Precursor;
GN   Name=GH2;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Revol A., Esquivel D., Santiago D., Barrera-Saldana H.;
RT   "Independent duplication of the growth hormone gene in three Anthropoidean
RT   lineages.";
RL   Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in growth control. Its major role in
CC       stimulating body growth is to stimulate the liver and other tissues to
CC       secrete IGF-1. It stimulates both the differentiation and proliferation
CC       of myoblasts. It also stimulates amino acid uptake and protein
CC       synthesis in muscle and other tissues.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed in the placenta.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; AF374233; AAL72285.1; -; Genomic_DNA.
DR   RefSeq; NP_001184097.1; NM_001197168.1.
DR   AlphaFoldDB; P58757; -.
DR   SMR; P58757; -.
DR   STRING; 9598.ENSPTRP00000016186; -.
DR   PaxDb; P58757; -.
DR   GeneID; 100505396; -.
DR   KEGG; ptr:100505396; -.
DR   CTD; 2689; -.
DR   eggNOG; ENOG502R5GJ; Eukaryota.
DR   InParanoid; P58757; -.
DR   Proteomes; UP000002277; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031982; C:vesicle; IEA:UniProt.
DR   GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR   GO; GO:0005131; F:growth hormone receptor binding; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0048513; P:animal organ development; IBA:GO_Central.
DR   GO; GO:0060396; P:growth hormone receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0045927; P:positive regulation of growth; IBA:GO_Central.
DR   GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR   GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IBA:GO_Central.
DR   GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Phosphoprotein; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000250"
FT   CHAIN           27..217
FT                   /note="Growth hormone variant"
FT                   /id="PRO_0000033063"
FT   MOD_RES         132
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01241"
FT   MOD_RES         176
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01241"
FT   CARBOHYD        166
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        79..191
FT                   /evidence="ECO:0000250"
FT   DISULFID        208..215
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   217 AA;  24991 MW;  1592A429075677DE CRC64;
     MAAGSRTSLL LAFGLLCLPW LQEGSAFPTI PLSRLFDNAM LRAHRLYQLA YDTYQEFEEA
     YILKEQKYSF LQNPQTSLCF SESIPTPSNR VKTQQKSNLE LLRISLLLIQ SWLEPVQLLR
     SVFANSLVYG ASDSNVYRHL KDLEEGIQTL MWRLEDGSPR TGQIFNQSYS KFDTKSHNDD
     ALLKNYGLLY CFRKDMDKVE TFLRIVQCRS VEGSCGF