ID   SOMA1_CARAU             Reviewed;         210 AA.
AC   O93359;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Somatotropin-1;
DE   AltName: Full=Growth hormone I;
DE   AltName: Full=Somatotropin I;
DE   Flags: Precursor;
GN   Name=gh1;
OS   Carassius auratus (Goldfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Carassius.
OX   NCBI_TaxID=7957;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8651695; DOI=10.1006/abbi.1996.0221;
RA   Law M.S., Cheng K.W., Fung T.K., Chan Y.H., Yu K.L., Chan K.M.;
RT   "Isolation and characterization of two distinct growth hormone cDNAs from
RT   the goldfish, Carassius auratus.";
RL   Arch. Biochem. Biophys. 330:19-23(1996).
CC   -!- FUNCTION: Growth hormone plays an important role in growth control and
CC       is involved in the regulation of several anabolic processes. Implicated
CC       as an osmoregulatory substance important for seawater adaptation.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; AF069398; AAC19389.1; -; mRNA.
DR   PIR; S69262; S69262.
DR   AlphaFoldDB; O93359; -.
DR   SMR; O93359; -.
DR   Ensembl; ENSCART00000005612; ENSCARP00000005283; ENSCARG00000002508.
DR   Proteomes; UP000515129; Genome assembly.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034975; Somatotropin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Metal-binding; Reference proteome; Secreted;
KW   Signal; Zinc.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000250"
FT   CHAIN           23..210
FT                   /note="Somatotropin-1"
FT                   /id="PRO_0000033014"
FT   BINDING         38
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         192
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   DISULFID        71..183
FT                   /evidence="ECO:0000250"
FT   DISULFID        200..208
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   210 AA;  23759 MW;  8B68724F79046669 CRC64;
     MARALVLLSV VLVSLLVNQG RASDNQRLFN NAVIRVQHLH QLAAKMINDF EDSLLPEERR
     QLSKIFPLSF CNSDYIEAPT GKDETQKSSM LKLLRVSFRL IESWEFPSQT LSGTVSNSLT
     VGNPNQITEK LADLKMGISV LIQACLDGQP NMDDNDSLPL PFEEFYLTMG DNSLRESFRL
     LACFKKDMHK VETYLRVANC RRSLDSNCTL