SOMA1_ONCNE
ID SOMA1_ONCNE Reviewed; 210 AA.
AC Q91222;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Somatotropin-1;
DE AltName: Full=Growth hormone I;
DE AltName: Full=Somatotropin I;
DE Flags: Precursor;
GN Name=gh1;
OS Oncorhynchus nerka (Sockeye salmon) (Salmo nerka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8023;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Liver;
RA Devlin R.H.;
RT "Sequence of sockeye salmon type 1 and 2 growth hormone genes and the
RT relationship of rainbow trout with Atlantic and Pacific salmon.";
RL Can. J. Fish. Aquat. Sci. 50:1738-1748(1993).
CC -!- FUNCTION: Growth hormone plays an important role in growth control and
CC is involved in the regulation of several anabolic processes. Implicated
CC as an osmoregulatory substance important for seawater adaptation.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC {ECO:0000305}.
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DR EMBL; U14551; AAA50757.1; -; Genomic_DNA.
DR AlphaFoldDB; Q91222; -.
DR SMR; Q91222; -.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0055074; P:calcium ion homeostasis; ISS:AgBase.
DR GO; GO:0042538; P:hyperosmotic salinity response; ISS:AgBase.
DR GO; GO:0010960; P:magnesium ion homeostasis; ISS:AgBase.
DR GO; GO:0045919; P:positive regulation of cytolysis; ISS:AgBase.
DR GO; GO:0050766; P:positive regulation of phagocytosis; ISS:AgBase.
DR GO; GO:0032930; P:positive regulation of superoxide anion generation; ISS:AgBase.
DR GO; GO:0002637; P:regulation of immunoglobulin production; ISS:AgBase.
DR GO; GO:0055078; P:sodium ion homeostasis; ISS:AgBase.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR034975; Somatotropin.
DR InterPro; IPR001400; Somatotropin/Prolactin.
DR InterPro; IPR018116; Somatotropin_CS.
DR PANTHER; PTHR11417; PTHR11417; 1.
DR PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR Pfam; PF00103; Hormone_1; 1.
DR PRINTS; PR00836; SOMATOTROPIN.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Hormone; Metal-binding; Secreted; Signal; Zinc.
FT SIGNAL 1..22
FT /evidence="ECO:0000250"
FT CHAIN 23..210
FT /note="Somatotropin-1"
FT /id="PRO_0000033038"
FT BINDING 38
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 192
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT DISULFID 71..183
FT /evidence="ECO:0000250"
FT DISULFID 200..208
FT /evidence="ECO:0000250"
SQ SEQUENCE 210 AA; 23789 MW; E061DD7C95C24CBF CRC64;
MGQVFLLMPV LLASCFLSQG AAIENQRLFN IAVSRVQHLH LLAQKMFNDF DGTLLPDERR
QLNKIFLLDF CISDSIVSPV DKHETQKSSV LKLLHISFRL IESWEYPSQT LIISNSLMVR
NANQISEKLS DLKVGINLLI TGSQDGVLSL DDNDSQHLPP YGNYYQNLGG EGNVRRNYEL
LACFKKDMHK VETYLTVAKC RKSLEANCTL