ID   SOMA1_XENLA             Reviewed;         214 AA.
AC   P12855; Q9PTI3;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   16-NOV-2001, sequence version 2.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Somatotropin-A;
DE   AltName: Full=Growth hormone A;
DE            Short=GH-A;
DE   Flags: Precursor;
GN   Name=gh-a; Synonyms=gha;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10618393; DOI=10.1073/pnas.97.1.190;
RA   Huang H., Brown D.D.;
RT   "Overexpression of Xenopus laevis growth hormone stimulates growth of
RT   tadpoles and frogs.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:190-194(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 76-214.
RC   TISSUE=Pituitary;
RX   PubMed=2734108; DOI=10.1093/nar/17.10.3974;
RA   Martens G.J.M., Groenen P.J.T.A., Braks A.A.M., Bussemakers M.J.G.;
RT   "Expression of two growth hormone genes in the Xenopus pituitary gland.";
RL   Nucleic Acids Res. 17:3974-3974(1989).
CC   -!- FUNCTION: Growth hormone plays an important role in growth control.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF193797; AAF05773.1; -; mRNA.
DR   EMBL; X14601; CAA32746.1; -; mRNA.
DR   PIR; S04353; S04353.
DR   RefSeq; NP_001083848.1; NM_001090379.1.
DR   RefSeq; XP_018092876.1; XM_018237387.1.
DR   AlphaFoldDB; P12855; -.
DR   SMR; P12855; -.
DR   GeneID; 399154; -.
DR   KEGG; xla:399154; -.
DR   CTD; 399154; -.
DR   Xenbase; XB-GENE-864898; gh1.S.
DR   OrthoDB; 1190548at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10S.
DR   Bgee; 399154; Expressed in brain.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034975; Somatotropin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000250"
FT   CHAIN           26..214
FT                   /note="Somatotropin-A"
FT                   /id="PRO_0000033009"
FT   DISULFID        77..187
FT                   /evidence="ECO:0000250"
FT   DISULFID        204..212
FT                   /evidence="ECO:0000250"
FT   CONFLICT        76
FT                   /note="S -> F (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        82
FT                   /note="I -> M (in Ref. 2; CAA32746)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        97
FT                   /note="L -> M (in Ref. 2; CAA32746)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        104..105
FT                   /note="LN -> QT (in Ref. 2; CAA32746)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        118
FT                   /note="N -> S (in Ref. 2; CAA32746)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        148
FT                   /note="Q -> R (in Ref. 2; CAA32746)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        160
FT                   /note="F -> V (in Ref. 2; CAA32746)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        164
FT                   /note="P -> L (in Ref. 2; CAA32746)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        176
FT                   /note="D -> E (in Ref. 2; CAA32746)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   214 AA;  24700 MW;  99B47F84105A90DB CRC64;
     MATGFCSSFG LLVVLLLKNV ADVGAFPSVP LFSLFTNAVS RAQYIHMLAA DTYRDYERTY
     ITDEQRHSNK NSHVVSCYSE TIPYPTDKDN THQKSDLELL RFSLNLIQSW LNPVQALNKV
     FSNNLVFGSS DVYERLKYLE EGIQALMQEL EDGSFRSFPF LRPPYERFDI NLRSDDALVK
     VYGLLSCFKK DMHKVETYLK VMKCRRFVES NCTI