ID   SOMA2_ACIGU             Reviewed;         190 AA.
AC   P26774;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Somatotropin-2;
DE   AltName: Full=Growth hormone II;
DE   AltName: Full=Somatotropin II;
GN   Name=gh2;
OS   Acipenser gueldenstaedtii (Russian sturgeon) (Danube sturgeon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Chondrostei; Acipenseriformes; Acipenseridae; Acipenser.
OX   NCBI_TaxID=7902;
RN   [1]
RP   PROTEIN SEQUENCE, AND DISULFIDE BONDS.
RC   TISSUE=Pituitary;
RX   PubMed=1576156; DOI=10.1016/0167-4838(92)90251-8;
RA   Yasuda A., Yamaguchi K., Noso T., Papkoff H., Polenov A.L., Nicoll C.S.,
RA   Kawauchi H.;
RT   "The complete amino acid sequence of growth hormone from sturgeon
RT   (Acipencer guldenstadti).";
RL   Biochim. Biophys. Acta 1120:297-304(1992).
CC   -!- FUNCTION: Growth hormone plays an important role in growth control and
CC       is involved in the regulation of several anabolic processes. Implicated
CC       as an osmoregulatory substance important for seawater adaptation.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P26774; -.
DR   SMR; P26774; -.
DR   PRIDE; P26774; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034975; Somatotropin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hormone; Secreted.
FT   CHAIN           1..190
FT                   /note="Somatotropin-2"
FT                   /id="PRO_0000181335"
FT   DISULFID        52..163
FT                   /evidence="ECO:0000269|PubMed:1576156"
FT   DISULFID        180..188
FT                   /evidence="ECO:0000269|PubMed:1576156"
SQ   SEQUENCE   190 AA;  21821 MW;  EAFFF0FE56181B18 CRC64;
     YPMIPLSSLF TNAVLRAQYL HQLAADIYKD FERTYMPNEQ RHSSKNSPSA FCYSETIPAP
     TGKDEAQQRS DVELLQFSLA LIQSWISPLQ SLSRVFTNSL VFLTSDRVFE KLKDLEEGIV
     ALMRDLGEGG FGSSTLLKLT YDMFDVNLRN NDVLFKNYGL LSCFKKDMHK VETYLKVMKC
     RRFVESNCTL