ID   SOMA2_CARAU             Reviewed;         210 AA.
AC   O93360;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Somatotropin-2;
DE   AltName: Full=Growth hormone II;
DE   AltName: Full=Somatotropin II;
DE   Flags: Precursor;
GN   Name=gh2;
OS   Carassius auratus (Goldfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Carassius.
OX   NCBI_TaxID=7957;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8651695; DOI=10.1006/abbi.1996.0221;
RA   Law M.S., Cheng K.W., Fung T.K., Chan Y.H., Yu K.L., Chan K.M.;
RT   "Isolation and characterization of two distinct growth hormone cDNAs from
RT   the goldfish, Carassius auratus.";
RL   Arch. Biochem. Biophys. 330:19-23(1996).
CC   -!- FUNCTION: Growth hormone plays an important role in growth control and
CC       is involved in the regulation of several anabolic processes. Implicated
CC       as an osmoregulatory substance important for seawater adaptation.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; AF069399; AAC19390.1; -; mRNA.
DR   PIR; S69263; S69263.
DR   AlphaFoldDB; O93360; -.
DR   SMR; O93360; -.
DR   Ensembl; ENSCART00000064542; ENSCARP00000061227; ENSCARG00000026878.
DR   Proteomes; UP000515129; Genome assembly.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034975; Somatotropin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Metal-binding; Reference proteome; Secreted;
KW   Signal; Zinc.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000250"
FT   CHAIN           23..210
FT                   /note="Somatotropin-2"
FT                   /id="PRO_0000033015"
FT   BINDING         38
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         192
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   DISULFID        71..183
FT                   /evidence="ECO:0000250"
FT   DISULFID        200..208
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   210 AA;  23767 MW;  3F54F2EAABD87731 CRC64;
     MARALVLLSV VLVSLLVNQG RASDNQRLFN NAVIRVQHLH QLAAKMINDF EDSLLPEERR
     QLSKIFPLSF CNSDYIEAPT GKDETQKSSM LKLLRISFRL IESWEYPSQT LSGTVSNSLT
     AGNPNQITEK LADLKMGINV LIKGSLDGQP NIDDNDSLPL PFEDFYLTMG ENNLRESFRL
     LACFKKDMHK VETYLRVANC RRSLDSNCTL