ID   SOMA2_ONCNE             Reviewed;         210 AA.
AC   Q91221;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Somatotropin-2;
DE   AltName: Full=Growth hormone II;
DE   AltName: Full=Somatotropin II;
DE   Flags: Precursor;
GN   Name=gh2;
OS   Oncorhynchus nerka (Sockeye salmon) (Salmo nerka).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8023;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Liver;
RA   Devlin R.H.;
RT   "Sequence of sockeye salmon type 1 and 2 growth hormone genes and the
RT   relationship of rainbow trout with Atlantic and Pacific salmon.";
RL   Can. J. Fish. Aquat. Sci. 50:1738-1748(1993).
CC   -!- FUNCTION: Growth hormone plays an important role in growth control and
CC       is involved in the regulation of several anabolic processes. Implicated
CC       as an osmoregulatory substance important for seawater adaptation.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; U14535; AAA50758.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q91221; -.
DR   SMR; Q91221; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0055074; P:calcium ion homeostasis; ISS:AgBase.
DR   GO; GO:0042538; P:hyperosmotic salinity response; ISS:AgBase.
DR   GO; GO:0010960; P:magnesium ion homeostasis; ISS:AgBase.
DR   GO; GO:0045919; P:positive regulation of cytolysis; ISS:AgBase.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; ISS:AgBase.
DR   GO; GO:0032930; P:positive regulation of superoxide anion generation; ISS:AgBase.
DR   GO; GO:0002637; P:regulation of immunoglobulin production; ISS:AgBase.
DR   GO; GO:0055078; P:sodium ion homeostasis; ISS:AgBase.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034975; Somatotropin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Hormone; Metal-binding; Secreted; Signal; Zinc.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000250"
FT   CHAIN           23..210
FT                   /note="Somatotropin-2"
FT                   /id="PRO_0000033039"
FT   BINDING         38
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         192
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   DISULFID        71..183
FT                   /evidence="ECO:0000250"
FT   DISULFID        200..208
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   210 AA;  23938 MW;  26989E8EDAD91267 CRC64;
     MGQVFLLMPV LLVSCFLSQG AAMENQRLFN IAVNRVQHLH LLAQKMFNDF EGTLLSDERR
     QLNKIFLLDF CNSDSIVSPI DKQETQKSSV LKLLRISFRL IESWEYPSQT LTISNSLMVR
     NSNQISEKLS DLKVGINLLI EGSQEGILSL DDNDSQHLPP YGNYYQNLGG DGNVRRNYEL
     LACFKKDMHK VETYLTVAKC RKSLEANCTL