ID   SOMA_ANAPL              Reviewed;         216 AA.
AC   P11228;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Somatotropin;
DE   AltName: Full=Growth hormone;
DE   Flags: Precursor;
GN   Name=GH;
OS   Anas platyrhynchos (Mallard) (Anas boschas).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC   Anatinae; Anas.
OX   NCBI_TaxID=8839;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=3342241; DOI=10.1016/0167-4781(88)90089-9;
RA   Chen H.-T., Pan F.-M., Chang W.-C.;
RT   "Purification of duck growth hormone and cloning of the complementary
RT   DNA.";
RL   Biochim. Biophys. Acta 949:247-251(1988).
CC   -!- FUNCTION: Growth hormone plays an important role in growth control.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; X07079; CAA30113.1; -; mRNA.
DR   RefSeq; NP_001297274.1; NM_001310345.1.
DR   AlphaFoldDB; P11228; -.
DR   SMR; P11228; -.
DR   Ensembl; ENSAPLT00020019969; ENSAPLP00020018467; ENSAPLG00020013139.
DR   GeneID; 101790997; -.
DR   KEGG; apla:101790997; -.
DR   CTD; 2688; -.
DR   OrthoDB; 1190548at2759; -.
DR   GO; GO:0005615; C:extracellular space; ISS:AgBase.
DR   GO; GO:0097153; F:cysteine-type endopeptidase activity involved in apoptotic process; ISS:AgBase.
DR   GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; ISS:AgBase.
DR   GO; GO:0010629; P:negative regulation of gene expression; ISS:AgBase.
DR   GO; GO:0035846; P:oviduct epithelium development; ISS:AgBase.
DR   GO; GO:0010628; P:positive regulation of gene expression; ISS:AgBase.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034975; Somatotropin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Metal-binding; Secreted; Signal; Zinc.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000250"
FT   CHAIN           26..216
FT                   /note="Somatotropin"
FT                   /id="PRO_0000033003"
FT   BINDING         46
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         198
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   DISULFID        78..189
FT                   /evidence="ECO:0000250"
FT   DISULFID        206..214
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   216 AA;  24896 MW;  3A10C0AC18BB30F0 CRC64;
     MAPGSWFSPL FITVITLGLQ WPQEAATFPA MPLSNLFANA VLRAQHLHLL AAETYKEFER
     SYIPEDQRHT NKNSQAFCYS ETIPAPTGKD DAQQKSDMEL LRFSLVLIQS WLTPVQYLSK
     VFTNNLVFGT SDRVFEKLKD LEEGIQALMR ELEDRSPRGP QLLKPTYDKF DIHLRNEDAL
     LKNYGLLSCF KKDLHKVETY LKVMKCRRFG ESNCTI