ID   SOMA_ASPFU              Reviewed;         784 AA.
AC   Q4WAR8;
DT   17-FEB-2016, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Transcriptional activator somA {ECO:0000305};
GN   Name=somA {ECO:0000303|PubMed:26529322}; ORFNames=AFUA_7G02260;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
RN   [2]
RP   INTERACTION WITH PTAB, DISRUPTION PHENOTYPE, AND FUNCTION.
RX   PubMed=26529322; DOI=10.1371/journal.ppat.1005205;
RA   Lin C.J., Sasse C., Gerke J., Valerius O., Irmer H., Frauendorf H.,
RA   Heinekamp T., Strassburger M., Tran V.T., Herzog B., Braus-Stromeyer S.A.,
RA   Braus G.H.;
RT   "Transcription factor somA is required for adhesion, development and
RT   virulence of the human pathogen Aspergillus fumigatus.";
RL   PLoS Pathog. 11:E1005205-E1005205(2015).
CC   -!- FUNCTION: Transcription factor that controls the expression of genes
CC       related to the process of conidiation and adherence and regulates
CC       biofilm formation (PubMed:26529322). Controls conidiation and adhesion
CC       primarily by affecting the expression of the three regulatory genes
CC       flbB, stuA and medA (PubMed:26529322). Required for virulence in an egg
CC       and a mouse infection model (PubMed:26529322).
CC       {ECO:0000269|PubMed:26529322}.
CC   -!- SUBUNIT: Interacts with ptaB. {ECO:0000269|PubMed:26529322}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Impairs conidiophore formation.
CC       {ECO:0000269|PubMed:26529322}.
CC   -!- SIMILARITY: Belongs to the FLO8 family. {ECO:0000305}.
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DR   EMBL; AAHF01000015; EAL84668.1; -; Genomic_DNA.
DR   RefSeq; XP_746706.1; XM_741613.1.
DR   AlphaFoldDB; Q4WAR8; -.
DR   STRING; 746128.CADAFUBP00008635; -.
DR   EnsemblFungi; EAL84668; EAL84668; AFUA_7G02260.
DR   GeneID; 3504272; -.
DR   KEGG; afm:AFUA_7G02260; -.
DR   VEuPathDB; FungiDB:Afu7g02260; -.
DR   eggNOG; ENOG502R28W; Eukaryota.
DR   HOGENOM; CLU_008468_0_0_1; -.
DR   InParanoid; Q4WAR8; -.
DR   OMA; IYEYFLR; -.
DR   OrthoDB; 727158at2759; -.
DR   PHI-base; PHI:5365; -.
DR   Proteomes; UP000002530; Chromosome 7.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR006594; LisH.
DR   Pfam; PF08513; LisH; 1.
DR   PROSITE; PS50896; LISH; 1.
PE   1: Evidence at protein level;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Virulence.
FT   CHAIN           1..784
FT                   /note="Transcriptional activator somA"
FT                   /id="PRO_0000435641"
FT   DOMAIN          43..75
FT                   /note="LisH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00126"
FT   REGION          75..122
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          212..295
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          424..726
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          764..784
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        83..115
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        212..233
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        244..258
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        271..295
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        449..473
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        558..591
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        604..620
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        627..642
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        678..695
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        696..712
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   784 AA;  84558 MW;  66A49F14D198B9A1 CRC64;
     MNQMNVTGMN PGAGGPVGGV PMMNNGSTAP RNDGNVNNIP ETMINNLNTY IYDYFLKRGY
     HECARALVKD ESIKLNTEPP TKTSPGHRRE DMNGVEGDAI MTDSKDGDKI KIPDDLPRPN
     LASESQQSSF LLDWFSLFWD FFWAQRKKGN SNDVRQYLQH TQNMMRLREQ QHNQLLRQQP
     VMPRQMGPLN MRRNGMVPAN LQKTVLQNNT GGLSQQQIAQ LQKNQQMHMM QQMQREHSDM
     DMNGHRPQSP SSAENAPSPS KRPRLENGPM NGQQLAPNGR GQGQAMPGQP NSQALLMQNG
     LNPRAMNPAQ FAGFQQQGPA AQQKSIQVYA QNLALHHSRS ALNNQGIPNG LMNPGVMPNQ
     TDLVPMPDGQ GMYPMNGDYY GTNGQMAQVR AGMQTPGGQH GNHALQDYQM QLMLLEQQNK
     RRLMMARQEQ DSMSRADGQP PMPGQQGLPP GTSPQGSRAG TSPNPNEQMK RGTPKMPQTG
     LPGSPNAADA MGQNRGSPAA MNFNGGQMPP DMAGGQFFMK GMPDAMGGPN GMRPPSSNPA
     FSGPQMGQPI PAGAVNRVPS GNWQQQQGQP MGPQQSPAQQ PQSTGTPQTQ NSMPPPQAPP
     AGANAARTSP QSQNAAPPTP QQANKPAPKK REPKDTARKR TTKKQPAAAA AAANTAATPS
     SEAEHPPTTP TPSTPITPQH PSSFNKAGPN PTTSAPQQPT SAPAPQPIVQ QPPPDQTQQS
     FNDLSIPDAS AFNLDFSALE NPDILENFDF DTFLNTDADT AGFGFDPNIS YPTDGVETGA
     GDGL