ID   SOMA_BALBO              Reviewed;         190 AA.
AC   P33092;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Somatotropin;
DE   AltName: Full=Growth hormone;
GN   Name=GH1;
OS   Balaenoptera borealis (Sei whale) (Pollack whale).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC   Balaenopteridae; Balaenoptera.
OX   NCBI_TaxID=9768;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=7115813;
RA   Yudaev N.A., Pankov Y.A., Bulatov A.A., Osipova T.A.;
RT   "Amino acid sequence of seiwhale somatotropin.";
RL   Biokhimiia 47:1059-1069(1982).
RN   [2]
RP   PRELIMINARY PARTIAL PROTEIN SEQUENCE.
RA   Osipova T.A., Bulatov A.A., Pankov Y.A.;
RT   "Structural studies of tryptic peptides from large cyanogen bromide
RT   fragments of sei whale (Balalnoptera borealis) somatotropin.";
RL   Bioorg. Khim. 4:1589-1599(1978).
CC   -!- FUNCTION: Plays an important role in growth control. Its major role in
CC       stimulating body growth is to stimulate the liver and other tissues to
CC       secrete IGF-1. It stimulates both the differentiation and proliferation
CC       of myoblasts. It also stimulates amino acid uptake and protein
CC       synthesis in muscle and other tissues.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   PIR; JN0387; JN0387.
DR   PIR; PN0140; PN0140.
DR   AlphaFoldDB; P33092; -.
DR   SMR; P33092; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034975; Somatotropin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hormone; Metal-binding;
KW   Phosphoprotein; Secreted; Zinc.
FT   CHAIN           1..190
FT                   /note="Somatotropin"
FT                   /id="PRO_0000181328"
FT   BINDING         19
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         172
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         105
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01241"
FT   DISULFID        52..163
FT                   /evidence="ECO:0000250"
FT   DISULFID        180..188
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   190 AA;  21835 MW;  09FBFF6DB14A75D6 CRC64;
     FPAMPLSSLF ANAVLRAQHL HELAADTYKE FERAYIPEGQ RYFLQNAQST GCFSEVIPTP
     ANKDEAQQRS DVELLRFSLL LIQSWLGPVQ FLEKAYANEL VFGTSDRVYE KLKDLEEGIQ
     ALMRELEDGS PRAGQILKQT YDKFDTNMRS DDALLKNYGL LSCFKKDLHK AETYLRVMKC
     RRFVESSCAF