ID   SOMA_CALJA              Reviewed;         217 AA.
AC   Q9GMB3;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Somatotropin;
DE   AltName: Full=Growth hormone;
DE   Flags: Precursor;
GN   Name=GH1;
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Wallis O.C., Wallis M.;
RT   "Cloning and characterisation of a putative growth hormone encoding gene
RT   from the marmoset (Callithrix jacchus).";
RL   Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in growth control. Its major role in
CC       stimulating body growth is to stimulate the liver and other tissues to
CC       secrete IGF-1. It stimulates both the differentiation and proliferation
CC       of myoblasts. It also stimulates amino acid uptake and protein
CC       synthesis in muscle and other tissues (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; AJ297563; CAC03481.1; -; Genomic_DNA.
DR   RefSeq; NP_001277275.1; NM_001290346.1.
DR   AlphaFoldDB; Q9GMB3; -.
DR   SMR; Q9GMB3; -.
DR   STRING; 9483.ENSCJAP00000036236; -.
DR   Ensembl; ENSCJAT00000102129; ENSCJAP00000069619; ENSCJAG00000075159.
DR   GeneID; 100392546; -.
DR   KEGG; cjc:100392546; -.
DR   CTD; 2688; -.
DR   eggNOG; ENOG502R5GJ; Eukaryota.
DR   GeneTree; ENSGT00950000182818; -.
DR   InParanoid; Q9GMB3; -.
DR   OrthoDB; 1190548at2759; -.
DR   Proteomes; UP000008225; Chromosome 5.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Hormone; Metal-binding; Phosphoprotein; Reference proteome;
KW   Secreted; Signal; Zinc.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000250"
FT   CHAIN           25..217
FT                   /note="Somatotropin"
FT                   /id="PRO_0000032976"
FT   BINDING         44
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         200
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         132
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01241"
FT   DISULFID        79..191
FT                   /evidence="ECO:0000250"
FT   DISULFID        208..215
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   217 AA;  24960 MW;  E102151A12CE6192 CRC64;
     MAAGSWTSLL LAFTLLCLPQ LREAGAFPTI PLSRLLDNAM LRAHRLHQLA FDTYQEFEEA
     YIPKEQKYSF LQNPQTSLCF SESIPTPASK KETQQKSNLE LLRMSLLLIQ SWFEPVQFLR
     SVFANSLLYG VSDSDVYEYL KDLEEGIQTL MGRLEDGSPR TGEIFMQTYR KFDVNSQNND
     ALLKNYGLLY CFRKDMDKVE TFLRIVQCRS VEGSCGF