ID   SOMA_CAPHI              Reviewed;         217 AA.
AC   P67931; P01247; P07289; Q29404;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Somatotropin;
DE   AltName: Full=Growth hormone;
DE   Flags: Precursor;
GN   Name=GH1;
OS   Capra hircus (Goat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Capra.
OX   NCBI_TaxID=9925;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Saanen;
RX   PubMed=3342884; DOI=10.1016/0014-5793(88)80020-6;
RA   Yamano Y., Oyabayashi K., Okuno M., Yato M., Kioka N., Manabe E., Hashi H.,
RA   Sakai H., Komano T., Utsumi K., Iritani A.;
RT   "Cloning and sequencing of cDNA that encodes goat growth hormone.";
RL   FEBS Lett. 228:301-304(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3375065; DOI=10.1093/nar/16.8.3578;
RA   Yato M., Yamano Y., Oyabayashi K., Okuno M., Kioka N., Manabe E., Hashi H.,
RA   Sakai H., Komano T., Utsumi K., Iritani A.;
RT   "Nucleotide sequence of the growth hormone gene cDNA from goat Capra hircus
RT   L. (Tokara).";
RL   Nucleic Acids Res. 16:3578-3578(1988).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Kioka N., Manabe E., Abe M., Hashi H., Yato M., Okuno M., Yamano Y.,
RA   Sakai H., Komano T., Utsumi K., Iritani A.;
RT   "Cloning and sequencing of goat growth hormone gene.";
RL   Agric. Biol. Chem. 53:1583-1587(1989).
CC   -!- FUNCTION: Plays an important role in growth control. Its major role in
CC       stimulating body growth is to stimulate the liver and other tissues to
CC       secrete IGF-1. It stimulates both the differentiation and proliferation
CC       of myoblasts. It also stimulates amino acid uptake and protein
CC       synthesis in muscle and other tissues.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; Y00767; CAA68736.1; -; mRNA.
DR   EMBL; X07035; CAA30083.1; -; mRNA.
DR   EMBL; D00476; BAA00368.1; -; Genomic_DNA.
DR   PIR; S00321; STGT.
DR   RefSeq; NP_001272515.1; NM_001285586.1.
DR   AlphaFoldDB; P67931; -.
DR   BMRB; P67931; -.
DR   SMR; P67931; -.
DR   STRING; 9925.ENSCHIP00000008280; -.
DR   Ensembl; ENSCHIT00000016039; ENSCHIP00000008280; ENSCHIG00000011515.
DR   GeneID; 100861230; -.
DR   KEGG; chx:100861230; -.
DR   CTD; 2688; -.
DR   GeneTree; ENSGT00950000182818; -.
DR   OrthoDB; 1190548at2759; -.
DR   Proteomes; UP000291000; Chromosome 19.
DR   Bgee; ENSCHIG00000011515; Expressed in ovary and 2 other tissues.
DR   GO; GO:0005615; C:extracellular space; ISS:AgBase.
DR   GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0030073; P:insulin secretion; ISS:AgBase.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034975; Somatotropin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Metal-binding; Phosphoprotein; Reference proteome;
KW   Secreted; Signal; Zinc.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000250"
FT   CHAIN           28..217
FT                   /note="Somatotropin"
FT                   /id="PRO_0000032979"
FT   BINDING         46
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         199
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         132
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01241"
FT   DISULFID        79..190
FT                   /evidence="ECO:0000250"
FT   DISULFID        207..215
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   217 AA;  24631 MW;  77EC37A102584429 CRC64;
     MMAAGPRTSL LLAFTLLCLP WTQVVGAFPA MSLSGLFANA VLRAQHLHQL AADTFKEFER
     TYIPEGQRYS IQNTQVAFCF SETIPAPTGK NEAQQKSDLE LLRISLLLIQ SWLGPLQFLS
     RVFTNSLVFG TSDRVYEKLK DLEEGILALM RELEDVTPRA GQILKQTYDK FDTNMRSDDA
     LLKNYGLLSC FRKDLHKTET YLRVMKCRRF GEASCAF