ID   SOMA_CAVPO              Reviewed;         216 AA.
AC   Q9JKM4;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Somatotropin;
DE   AltName: Full=Growth hormone;
DE   Flags: Precursor;
GN   Name=GH1; Synonyms=GH;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Odorico D.M., Fuller P.J., Herington A.C.;
RT   "Cloning and sequence of guinea pig growth hormone (GH).";
RL   Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in growth control. Its major role in
CC       stimulating body growth is to stimulate the liver and other tissues to
CC       secrete IGF-1. It stimulates both the differentiation and proliferation
CC       of myoblasts. It also stimulates amino acid uptake and protein
CC       synthesis in muscle and other tissues (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; AF233853; AAF36409.1; -; mRNA.
DR   RefSeq; NP_001166330.1; NM_001172859.1.
DR   AlphaFoldDB; Q9JKM4; -.
DR   SMR; Q9JKM4; -.
DR   STRING; 10141.ENSCPOP00000016097; -.
DR   Ensembl; ENSCPOT00000022548; ENSCPOP00000016097; ENSCPOG00000022220.
DR   GeneID; 100379559; -.
DR   KEGG; cpoc:100379559; -.
DR   CTD; 2688; -.
DR   eggNOG; ENOG502R5GJ; Eukaryota.
DR   GeneTree; ENSGT00950000182818; -.
DR   HOGENOM; CLU_088274_2_1_1; -.
DR   InParanoid; Q9JKM4; -.
DR   OMA; QTAFCFS; -.
DR   OrthoDB; 1190548at2759; -.
DR   TreeFam; TF332592; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000022220; Expressed in pituitary gland and 9 other tissues.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034975; Somatotropin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Metal-binding; Phosphoprotein; Reference proteome;
KW   Secreted; Signal; Zinc.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000250"
FT   CHAIN           27..216
FT                   /note="Somatotropin"
FT                   /id="PRO_0000032980"
FT   BINDING         45
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         198
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         131
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01241"
FT   DISULFID        78..189
FT                   /evidence="ECO:0000250"
FT   DISULFID        206..214
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   216 AA;  24822 MW;  45996BE119B08DD3 CRC64;
     MAAGSQATWL LIFALLCLPW PKEVRGFPAM PLSSLFGNAV LRAQHLHQLA ADTYKEFERT
     YIPEGQRYSI HNTQTAFCFS ETIPAPTDKE EAQQRSDVEL LHFSLLLIQS WLGPVQFLSR
     VFTNSLVFGT SDRVYEKLKD LEEGIQALMR ELEDGTPRAG QILKQTYDKF DTNLRSNDAL
     LKNYGLLSCF RKDLHRTETY LRVMKCRRFV ESSCAF