ID   SOMA_CHEMY              Reviewed;         191 AA.
AC   P34005;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Somatotropin;
DE   AltName: Full=Growth hormone;
GN   Name=GH;
OS   Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC   Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX   NCBI_TaxID=8469;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=2707583; DOI=10.1016/0016-6480(89)90097-x;
RA   Yasuda A., Yamaguchi K., Papkoff H., Yokoo Y., Kawauchi H.;
RT   "The complete amino acid sequence of growth hormone from the sea turtle
RT   (Chelonia mydas).";
RL   Gen. Comp. Endocrinol. 73:242-251(1989).
CC   -!- FUNCTION: Growth hormone plays an important role in growth control and
CC       is involved in the regulation of several anabolic processes. Implicated
CC       as an osmoregulatory substance important for seawater adaptation.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   PIR; A60625; A60625.
DR   AlphaFoldDB; P34005; -.
DR   SMR; P34005; -.
DR   STRING; 8469.XP_007069102.1; -.
DR   eggNOG; ENOG502R5GJ; Eukaryota.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034975; Somatotropin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hormone; Metal-binding;
KW   Secreted; Zinc.
FT   CHAIN           1..191
FT                   /note="Somatotropin"
FT                   /id="PRO_0000181332"
FT   BINDING         20
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         173
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   DISULFID        53..164
FT                   /evidence="ECO:0000269|PubMed:2707583"
FT   DISULFID        181..189
FT                   /evidence="ECO:0000269|PubMed:2707583"
SQ   SEQUENCE   191 AA;  22050 MW;  472DAF0B30890659 CRC64;
     AFPAMPLSSL FANAVLRAQH LHLLAADTYK EFERTYIPEE QRHSNKISQS ASCYSETIPA
     PTGKDDAEQK SDMELLRFSL ILIQSWLNPV QFLSRVFTNS LVFGTSDRVY EKLRDLEEGI
     QALMRELEDG SLRGFQVLRP TYDKFDINLR NEDALLKNYG LLSCFKKDLH KVETYLKLMK
     CRRFGESNCT I