SOMA_CHICK
ID SOMA_CHICK Reviewed; 216 AA.
AC P08998; Q53Z10;
DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-1992, sequence version 2.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Somatotropin;
DE AltName: Full=Growth hormone;
DE Flags: Precursor;
GN Name=GH;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3174454; DOI=10.1093/nar/16.19.9339;
RA Lamb I.C., Galehouse D.M., Foster D.N.;
RT "Chicken growth hormone cDNA sequence.";
RL Nucleic Acids Res. 16:9339-9339(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Pituitary;
RA Zhvirblis G.S., Gorbulev V.G., Rubtsov P.M., Karapetyan R.V.,
RA Zhuravlev I.V., Fisinin V.I., Skryabin K.G., Baev A.A.;
RT "Genetic engineering of peptide hormones: I. Cloning and primary structure
RT of cDNA of chicken growth hormone.";
RL Mol. Biol. (Mosk.) 21:1324-1328(1987).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3482121;
RA Zhvirblis G.S., Gorbulev V.G., Rubtsov P.M., Karapetian R.V.,
RA Zhuravlev I.V.;
RT "Genetic engineering of peptide hormones. I. Cloning and primary structure
RT of cDNA of chicken growth hormone.";
RL Mol. Biol. (Mosk.) 21:1620-1624(1987).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1975228; DOI=10.1016/0305-0491(90)90046-v;
RA Baum D., Graser G., Heib M., Krampitz G.;
RT "Chicken growth hormone: cDNA-synthesis and base sequence.";
RL Comp. Biochem. Physiol. 96B:491-495(1990).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1555772; DOI=10.1016/0378-1119(92)90382-y;
RA Tanaka M., Hosokawa Y., Watahiki M., Nakashima K.;
RT "Structure of the chicken growth hormone-encoding gene and its promoter
RT region.";
RL Gene 112:235-239(1992).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Yellow Wai Chow;
RA Ip S.C.Y., Chan C., Leung F.C.;
RT "Chicken growth hormone genomic sequence (Yellow Wai Chow strain).";
RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Neuroretina;
RX PubMed=12960021; DOI=10.1210/en.2003-0651;
RA Baudet M.-L., Sanders E.J., Harvey S.;
RT "Retinal growth hormone in the chick embryo.";
RL Endocrinology 144:5459-5468(2003).
RN [8]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Sun B., Nie Q., Lei M., Zhang X.;
RT "Single nucleotide polymorphisms of chicken whole growth hormone gene and
RT their relation to growth traits.";
RL Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Growth hormone plays an important role in growth control.
CC -!- INTERACTION:
CC P08998; Q69283: SORF2; Xeno; NbExp=5; IntAct=EBI-10951437, EBI-10951469;
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC {ECO:0000305}.
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DR EMBL; X12608; CAA31127.1; -; mRNA.
DR EMBL; M35609; AAA48780.1; -; mRNA.
DR EMBL; X17618; CAA35619.1; -; mRNA.
DR EMBL; D10484; BAA01365.1; -; Genomic_DNA.
DR EMBL; AF289468; AAG01029.1; -; Genomic_DNA.
DR EMBL; AY373631; AAQ81586.1; -; mRNA.
DR EMBL; AY461843; AAR23809.1; -; Genomic_DNA.
DR PIR; JH0630; A60509.
DR RefSeq; NP_989690.1; NM_204359.2.
DR AlphaFoldDB; P08998; -.
DR SMR; P08998; -.
DR IntAct; P08998; 1.
DR STRING; 9031.ENSGALP00000000327; -.
DR PaxDb; P08998; -.
DR Ensembl; ENSGALT00000000328; ENSGALP00000000327; ENSGALG00000000249.
DR GeneID; 378781; -.
DR KEGG; gga:378781; -.
DR CTD; 14599; -.
DR VEuPathDB; HostDB:geneid_378781; -.
DR eggNOG; ENOG502R5GJ; Eukaryota.
DR GeneTree; ENSGT00950000182818; -.
DR HOGENOM; CLU_088274_2_1_1; -.
DR InParanoid; P08998; -.
DR OMA; QTAFCFS; -.
DR OrthoDB; 1190548at2759; -.
DR PhylomeDB; P08998; -.
DR TreeFam; TF332592; -.
DR Reactome; R-GGA-422085; Synthesis, secretion, and deacylation of Ghrelin.
DR Reactome; R-GGA-982772; Growth hormone receptor signaling.
DR PRO; PR:P08998; -.
DR Proteomes; UP000000539; Chromosome 27.
DR Bgee; ENSGALG00000000249; Expressed in spleen and 11 other tissues.
DR GO; GO:0005615; C:extracellular space; IDA:AgBase.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0030141; C:secretory granule; IEA:Ensembl.
DR GO; GO:0005802; C:trans-Golgi network; IEA:Ensembl.
DR GO; GO:0097153; F:cysteine-type endopeptidase activity involved in apoptotic process; IDA:AgBase.
DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR GO; GO:0005131; F:growth hormone receptor binding; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0048513; P:animal organ development; IBA:GO_Central.
DR GO; GO:0032869; P:cellular response to insulin stimulus; IEA:Ensembl.
DR GO; GO:0060396; P:growth hormone receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IDA:AgBase.
DR GO; GO:0010629; P:negative regulation of gene expression; IDA:AgBase.
DR GO; GO:0035846; P:oviduct epithelium development; IDA:AgBase.
DR GO; GO:0010628; P:positive regulation of gene expression; IDA:AgBase.
DR GO; GO:0045927; P:positive regulation of growth; IBA:GO_Central.
DR GO; GO:0040018; P:positive regulation of multicellular organism growth; IEA:Ensembl.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IBA:GO_Central.
DR GO; GO:0050691; P:regulation of defense response to virus by host; IMP:AgBase.
DR GO; GO:0032094; P:response to food; IEA:Ensembl.
DR GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR034975; Somatotropin.
DR InterPro; IPR001400; Somatotropin/Prolactin.
DR InterPro; IPR018116; Somatotropin_CS.
DR PANTHER; PTHR11417; PTHR11417; 1.
DR PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR Pfam; PF00103; Hormone_1; 1.
DR PRINTS; PR00836; SOMATOTROPIN.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Hormone; Metal-binding; Reference proteome; Secreted;
KW Signal; Zinc.
FT SIGNAL 1..25
FT /evidence="ECO:0000250"
FT CHAIN 26..216
FT /note="Somatotropin"
FT /id="PRO_0000033004"
FT BINDING 45
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 198
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT DISULFID 78..189
FT /evidence="ECO:0000250"
FT DISULFID 206..214
FT /evidence="ECO:0000250"
FT CONFLICT 101
FT /note="L -> P (in Ref. 1; CAA31127)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 216 AA; 24713 MW; 70EC907C9387ED09 CRC64;
MAPGSWFSPL LIAVVTLGLP QEAAATFPAM PLSNLFANAV LRAQHLHLLA AETYKEFERT
YIPEDQRYTN KNSQAAFCYS ETIPAPTGKD DAQQKSDMEL LRFSLVLIQS WLTPVQYLSK
VFTNNLVFGT SDRVFEKLKD LEEGIQALMR ELEDRSPRGP QLLRPTYDKF DIHLRNEDAL
LKNYGLLSCF KKDLHKVETY LKVMKCRRFG ESNCTI
