ID   SOMA_CORLV              Reviewed;         210 AA.
AC   O13188;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Somatotropin;
DE   AltName: Full=Growth hormone;
DE   Flags: Precursor;
GN   Name=gh;
OS   Coregonus lavaretus (Common whitefish) (Salmo lavaretus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Coregoninae; Coregonus.
OX   NCBI_TaxID=59291;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9136024; DOI=10.1093/genetics/146.1.355;
RA   Hamada M., Kido Y., Himberg M., Reist J.D., Ying C., Hasegawa M., Okada N.;
RT   "A newly isolated family of short interspersed repetitive elements (SINEs)
RT   in coregonid fishes (whitefish) with sequences that are almost identical to
RT   those of the SmaI family of repeats: possible evidence for the horizontal
RT   transfer of SINEs.";
RL   Genetics 146:355-367(1997).
CC   -!- FUNCTION: Growth hormone plays an important role in growth control and
CC       is involved in the regulation of several anabolic processes. Implicated
CC       as an osmoregulatory substance important for seawater adaptation.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB001865; BAA19490.1; -; Genomic_DNA.
DR   AlphaFoldDB; O13188; -.
DR   SMR; O13188; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0055074; P:calcium ion homeostasis; ISS:AgBase.
DR   GO; GO:0042538; P:hyperosmotic salinity response; ISS:AgBase.
DR   GO; GO:0010960; P:magnesium ion homeostasis; ISS:AgBase.
DR   GO; GO:0045919; P:positive regulation of cytolysis; ISS:AgBase.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; ISS:AgBase.
DR   GO; GO:0032930; P:positive regulation of superoxide anion generation; ISS:AgBase.
DR   GO; GO:0002637; P:regulation of immunoglobulin production; ISS:AgBase.
DR   GO; GO:0055078; P:sodium ion homeostasis; ISS:AgBase.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034975; Somatotropin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Hormone; Metal-binding; Secreted; Signal; Zinc.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000250"
FT   CHAIN           23..210
FT                   /note="Somatotropin"
FT                   /id="PRO_0000033018"
FT   BINDING         38
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         192
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   DISULFID        71..183
FT                   /evidence="ECO:0000250"
FT   DISULFID        200..208
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   210 AA;  23902 MW;  D7B4705AB445B267 CRC64;
     MGQVFLLMPV LLVSGFLSQG AAMENQRLFN IAVNRVQHLH LMAQKMFNDF EGTLLPDERR
     QLNKIFLLDF CNSDSIVSPI DKHETQKSSV LKLLHISFRL IESWEYPSQT LTISNSLMVR
     NSNQISEKLG DLKVGINLLI KGSQDGVLSL DDNDFQQLPP YGNYYQNLGG DGNVRRNYEL
     LACFKKDMHK VETYLTVAKC RKSLEANCTL