ID   SOMA_CRONO              Reviewed;         190 AA.
AC   P55755;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Somatotropin;
DE   AltName: Full=Growth hormone;
GN   Name=GH;
OS   Crocodylus novaeguineae (Crocodile).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Longirostres; Crocodylidae;
OC   Crocodylus.
OX   NCBI_TaxID=8503;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Pituitary;
RX   PubMed=7628683; DOI=10.1006/gcen.1995.1066;
RA   Noso T., Lance V.A., Kawauchi H.;
RT   "Complete amino acid sequence of crocodile growth hormone.";
RL   Gen. Comp. Endocrinol. 98:244-252(1995).
CC   -!- FUNCTION: Growth hormone plays an important role in growth control and
CC       involved in the regulation of several anabolic processes.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P55755; -.
DR   SMR; P55755; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034975; Somatotropin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hormone; Metal-binding;
KW   Secreted; Zinc.
FT   CHAIN           1..190
FT                   /note="Somatotropin"
FT                   /id="PRO_0000181333"
FT   BINDING         19
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         172
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   DISULFID        52..163
FT                   /evidence="ECO:0000250"
FT   DISULFID        180..188
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   190 AA;  22008 MW;  7D8EC7940A50E35A CRC64;
     FPAMPLSNLF ANAVLRAQHL YLLAAETYKE FERSYIPEEQ RHSNKNSQSA FCYSETIPAP
     TGKDDAQQKS DMELLRFSLV LVQSWLNPVQ FLSRVFTNSL VFGTSDRVFE KLRDLEEGIQ
     ALMRELEDGS HRGPQILKPT YEKFDINLRN EDALLKNYGL LSCFKKDLHK VETYLKLMKC
     RRFGESNCSI