ID   SOMA_CTEID              Reviewed;         210 AA.
AC   P69158; P20390; Q00220; Q00221;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Somatotropin;
DE   AltName: Full=Growth hormone;
DE   Flags: Precursor;
GN   Name=gh;
OS   Ctenopharyngodon idella (Grass carp) (Leuciscus idella).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Xenocyprididae; Xenocypridinae; Ctenopharyngodon.
OX   NCBI_TaxID=7959;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=1932119; DOI=10.1016/0167-4781(91)90110-8;
RA   Ho W.K.K., Wong M.W., Chan A.P.Y.;
RT   "Cloning and sequencing of the grass carp (Ctenopharyngodon idellus) growth
RT   hormone gene.";
RL   Biochim. Biophys. Acta 1090:245-248(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2742587; DOI=10.1016/0006-291x(89)91375-2;
RA   Ho W.K.K., Tsang W.H., Dias N.P.;
RT   "Cloning of the grass carp growth hormone cDNA.";
RL   Biochem. Biophys. Res. Commun. 161:1239-1243(1989).
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Pituitary;
RX   PubMed=1426941; DOI=10.1016/0016-6480(92)90045-l;
RA   Chang Y.S., Liu C.S., Huang F.-L., Lo T.B.;
RT   "The primary structures of growth hormones of three cyprinid species:
RT   bighead carp, silver carp, and grass carp.";
RL   Gen. Comp. Endocrinol. 87:385-393(1992).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Liver;
RX   PubMed=1633815; DOI=10.1111/j.1432-1033.1992.tb17091.x;
RA   Zhu Z., He L., Chen T.T.;
RT   "Primary-structural and evolutionary analyses of the growth-hormone gene
RT   from grass carp (Ctenopharyngodon idellus).";
RL   Eur. J. Biochem. 207:643-648(1992).
CC   -!- FUNCTION: Growth hormone plays an important role in growth control.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; M27094; AAA58724.1; -; mRNA.
DR   EMBL; X60419; CAA42948.1; -; Genomic_DNA.
DR   EMBL; X60474; CAA43007.1; -; mRNA.
DR   EMBL; X60988; CAA43304.1; -; Genomic_DNA.
DR   PIR; A32424; A32424.
DR   AlphaFoldDB; P69158; -.
DR   SMR; P69158; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034975; Somatotropin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Metal-binding; Secreted; Signal; Zinc.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   CHAIN           24..210
FT                   /note="Somatotropin"
FT                   /id="PRO_0000033019"
FT   BINDING         38
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         192
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   DISULFID        71..183
FT                   /evidence="ECO:0000250"
FT   DISULFID        200..208
FT                   /evidence="ECO:0000250"
FT   CONFLICT        73
FT                   /note="S -> C (in Ref. 2 and 3)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        112
FT                   /note="S -> R (in Ref. 3; CAA43007)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        114
FT                   /note="A -> Q (in Ref. 2 and 3)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   210 AA;  23580 MW;  98A8B3FECD52D098 CRC64;
     MARALVLLSV VLVSLLVNQG TASENQRLFN NAVIRVQHLH QLAAKMINDF EDNLLPEERR
     QLSKIFPLSF CNSDSIEAPT GKDETQKSSM LKLLRISFRL IESWEFPSQT LSGAVSNSLT
     VGNPNQITEK LADLKVGISV LIKGCLDGQP NMDDNDSLPL PFEDFYLTMG ESSLRESFRL
     LACFKKDMHK VETYLRVANC RRSLDSNCTL