ID   SOMA_CYPCA              Reviewed;         210 AA.
AC   P10298;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 2.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Somatotropin;
DE   AltName: Full=Growth hormone;
DE   Flags: Precursor;
GN   Name=gh;
OS   Cyprinus carpio (Common carp).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Cyprinus.
OX   NCBI_TaxID=7962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2400791; DOI=10.1016/0167-4781(90)90126-m;
RA   Chiou C.S., Chen H.T., Chang W.-C.;
RT   "The complete nucleotide sequence of the growth-hormone gene from the
RT   common carp (Cyprinus carpio).";
RL   Biochim. Biophys. Acta 1087:91-94(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=2753359; DOI=10.1016/0378-1119(89)90078-4;
RA   Koren Y., Sarid S., Ber R., Daniel V.;
RT   "Carp growth hormone: molecular cloning and sequencing of cDNA.";
RL   Gene 77:309-315(1989).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 24-56.
RC   TISSUE=Pituitary;
RX   PubMed=2920175; DOI=10.1016/0167-4781(89)90045-6;
RA   Chao S.-C., Pan F.-M., Chang W.-C.;
RT   "Purification of carp growth hormone and cloning of the complementary
RT   DNA.";
RL   Biochim. Biophys. Acta 1007:233-236(1989).
CC   -!- FUNCTION: Growth hormone plays an important role in growth control.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; X51969; CAA36228.1; -; Genomic_DNA.
DR   EMBL; M27000; AAA49208.1; -; mRNA.
DR   EMBL; X13670; CAA31963.1; -; mRNA.
DR   PIR; JS0180; JS0180.
DR   PIR; S02764; S02764.
DR   RefSeq; XP_018951738.1; XM_019096193.1.
DR   AlphaFoldDB; P10298; -.
DR   SMR; P10298; -.
DR   Ensembl; ENSCCRT00000059274; ENSCCRP00000054685; ENSCCRG00000029250.
DR   Ensembl; ENSCCRT00010062241; ENSCCRP00010056785; ENSCCRG00010023755.
DR   Ensembl; ENSCCRT00015066301; ENSCCRP00015064188; ENSCCRG00015026164.
DR   Ensembl; ENSCCRT00020064625; ENSCCRP00020058638; ENSCCRG00020027818.
DR   Ensembl; ENSCCRT00020064651; ENSCCRP00020058664; ENSCCRG00020027818.
DR   Ensembl; ENSCCRT00020064695; ENSCCRP00020058706; ENSCCRG00020027818.
DR   GeneID; 109104194; -.
DR   KEGG; ccar:109081196; -.
DR   GeneTree; ENSGT00950000182818; -.
DR   OrthoDB; 1190548at2759; -.
DR   Proteomes; UP000694384; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034975; Somatotropin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hormone; Metal-binding;
KW   Reference proteome; Secreted; Signal; Zinc.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000269|PubMed:2920175"
FT   CHAIN           24..210
FT                   /note="Somatotropin"
FT                   /id="PRO_0000033020"
FT   BINDING         38
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         192
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   DISULFID        71..183
FT                   /evidence="ECO:0000250"
FT   DISULFID        200..208
FT                   /evidence="ECO:0000250"
FT   CONFLICT        4
FT                   /note="V -> A (in Ref. 3; CAA31963)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        80
FT                   /note="A -> T (in Ref. 3; CAA31963)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        99
FT                   /note="H -> R (in Ref. 3; CAA31963)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        110
FT                   /note="S -> T (in Ref. 3; CAA31963)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        127
FT                   /note="L -> I (in Ref. 3; CAA31963)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        143..144
FT                   /note="QA -> KG (in Ref. 3; CAA31963)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   210 AA;  23765 MW;  C0F55D2D5A03E763 CRC64;
     MARVLVLLSV VLVSLLVNQG RASDNQRLFN NAVIRVQHLH QLAAKMINDF EDSLLPEERR
     QLSKIFPLSF CNSDYIEAPA GKDETQKSSM LKLLRISFHL IESWEFPSQS LSGTVSNSLT
     VGNPNQLTEK LADLKMGISV LIQACLDGQP NMDDNDSLPL PFEDFYLTMG ENNLRESFRL
     LACFKKDMHK VETYLRVANC RRSLDSNCTL