ID   SOMA_ESOLU              Reviewed;         209 AA.
AC   P34744;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 2.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Somatotropin;
DE   AltName: Full=Growth hormone;
DE   Flags: Precursor;
GN   Name=gh;
OS   Esox lucius (Northern pike).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC   Esocidae; Esox.
OX   NCBI_TaxID=8010;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=1308808;
RA   Schneider J.F., Myster S.H., Hackett P.B., Guise K.S., Faras A.J.;
RT   "Molecular cloning and sequence analysis of the cDNA for northern pike
RT   (Esox lucius) growth hormone.";
RL   Mol. Mar. Biol. Biotechnol. 1:106-112(1992).
CC   -!- FUNCTION: Growth hormone plays an important role in growth control and
CC       is involved in the regulation of several anabolic processes. Implicated
CC       as an osmoregulatory substance important for seawater adaptation.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; S66470; AAB28215.1; -; mRNA.
DR   RefSeq; NP_001290869.1; NM_001303940.1.
DR   AlphaFoldDB; P34744; -.
DR   SMR; P34744; -.
DR   STRING; 8010.XP_010890793.1; -.
DR   GeneID; 105023357; -.
DR   KEGG; els:105023357; -.
DR   CTD; 2688; -.
DR   OrthoDB; 1190548at2759; -.
DR   Proteomes; UP000265140; LG25.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034975; Somatotropin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Metal-binding; Reference proteome; Secreted;
KW   Signal; Zinc.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000250"
FT   CHAIN           23..209
FT                   /note="Somatotropin"
FT                   /id="PRO_0000033022"
FT   BINDING         38
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         191
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   DISULFID        71..182
FT                   /evidence="ECO:0000250"
FT   DISULFID        199..207
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   209 AA;  24008 MW;  F59582A3136EF379 CRC64;
     MGQVFLLMPV LLVAGYLSLG AAMENQRLFN IAVNRVQHLH LLAQKMFNDF EGTLLPDERR
     QLNKIFLLDF CNSDSIVSPI DKHETQKSSV LKLLHISFRL IESWEYPSQT LTHTMSNNLN
     QNQMSEKLSN LKVGINLLIK GNQEDVPSLD DNDSQQLLPY GNYYQNLGDN DNVRRNYELL
     ACFKKDMHKV ETYLTVAKCR KSLEANCTL