ID   SOMA_FELCA              Reviewed;         216 AA.
AC   P46404;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Somatotropin;
DE   AltName: Full=Growth hormone;
DE   Flags: Precursor;
GN   Name=GH1;
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX   NCBI_TaxID=9685;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=8654953; DOI=10.1016/0378-1119(95)00726-1;
RA   Warren W.C., Bentle K.A., Bogosian G.;
RT   "Cloning of the cDNAs coding for cat growth hormone and prolactin.";
RL   Gene 168:247-249(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=7642118; DOI=10.1016/0378-1119(95)00221-q;
RA   Castro-Peralta F., Barrera-Saldana H.A.;
RT   "Cloning and sequencing of cDNA encoding the cat growth hormone.";
RL   Gene 160:311-312(1995).
CC   -!- FUNCTION: Plays an important role in growth control. Its major role in
CC       stimulating body growth is to stimulate the liver and other tissues to
CC       secrete IGF-1. It stimulates both the differentiation and proliferation
CC       of myoblasts. It also stimulates amino acid uptake and protein
CC       synthesis in muscle and other tissues.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; U25973; AAA67294.1; -; mRNA.
DR   EMBL; U13390; AAA96142.1; -; mRNA.
DR   PIR; JC4632; JC4632.
DR   RefSeq; NP_001009337.1; NM_001009337.1.
DR   AlphaFoldDB; P46404; -.
DR   SMR; P46404; -.
DR   STRING; 9685.ENSFCAP00000003232; -.
DR   GeneID; 493931; -.
DR   KEGG; fca:493931; -.
DR   CTD; 2688; -.
DR   eggNOG; ENOG502R5GJ; Eukaryota.
DR   InParanoid; P46404; -.
DR   OrthoDB; 1190548at2759; -.
DR   Proteomes; UP000011712; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR   GO; GO:0005131; F:growth hormone receptor binding; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0048513; P:animal organ development; IBA:GO_Central.
DR   GO; GO:0060396; P:growth hormone receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0045927; P:positive regulation of growth; IBA:GO_Central.
DR   GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR   GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IBA:GO_Central.
DR   GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034975; Somatotropin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Metal-binding; Phosphoprotein; Reference proteome;
KW   Secreted; Signal; Zinc.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000250"
FT   CHAIN           27..216
FT                   /note="Somatotropin"
FT                   /id="PRO_0000032983"
FT   BINDING         45
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         198
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         131
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01241"
FT   DISULFID        78..189
FT                   /evidence="ECO:0000250"
FT   DISULFID        206..214
FT                   /evidence="ECO:0000250"
FT   CONFLICT        7
FT                   /note="N -> T (in Ref. 2; AAA96142)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        26
FT                   /note="T -> A (in Ref. 2; AAA96142)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        159
FT                   /note="G -> A (in Ref. 2; AAA96142)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        181
FT                   /note="L -> P (in Ref. 2; AAA96142)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   216 AA;  24454 MW;  05820239A7D292C6 CRC64;
     MAAGPRNSVL LAFALLCLPW PQEVGTFPAM PLSSLFANAV LRAQHLHQLA ADTYKEFERA
     YIPEGQRYSI QNAQAAFCFS ETIPAPTGKD EAQQRSDVEL LRFSLLLIQS WLGPVQFLSR
     VFTNSLVFGT SDRVYEKLKD LEEGIQALMR ELEDGSPRGG QILKQTYDKF DTNLRSDDAL
     LKNYGLLSCF KKDLHKAETY LRVMKCRRFV ESSCAF