SOMA_GALSE
ID SOMA_GALSE Reviewed; 217 AA.
AC Q9GKA1;
DT 16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Somatotropin;
DE AltName: Full=Growth hormone;
DE Flags: Precursor;
GN Name=GH1;
OS Galago senegalensis (Northern lesser bushbaby) (Senegal bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Galago.
OX NCBI_TaxID=9465;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11141192; DOI=10.1093/oxfordjournals.molbev.a003719;
RA Adkins R.M., Nekrutenko A., Li W.-H.;
RT "Bushbaby growth hormone is much more similar to nonprimate growth hormones
RT than to rhesus monkey and human growth hormones.";
RL Mol. Biol. Evol. 18:55-61(2001).
CC -!- FUNCTION: Plays an important role in growth control. Its major role in
CC stimulating body growth is to stimulate the liver and other tissues to
CC secrete IGF-1. It stimulates both the differentiation and proliferation
CC of myoblasts. It also stimulates amino acid uptake and protein
CC synthesis in muscle and other tissues.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC {ECO:0000305}.
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DR EMBL; AF292938; AAG44952.1; -; Genomic_DNA.
DR AlphaFoldDB; Q9GKA1; -.
DR SMR; Q9GKA1; -.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR034975; Somatotropin.
DR InterPro; IPR001400; Somatotropin/Prolactin.
DR InterPro; IPR018116; Somatotropin_CS.
DR PANTHER; PTHR11417; PTHR11417; 1.
DR PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR Pfam; PF00103; Hormone_1; 1.
DR PRINTS; PR00836; SOMATOTROPIN.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Hormone; Metal-binding; Secreted; Signal; Zinc.
FT SIGNAL 1..26
FT /evidence="ECO:0000250"
FT CHAIN 27..217
FT /note="Somatotropin"
FT /id="PRO_0000032984"
FT BINDING 46
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 199
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT DISULFID 79..190
FT /evidence="ECO:0000250"
FT DISULFID 207..215
FT /evidence="ECO:0000250"
SQ SEQUENCE 217 AA; 24481 MW; 2FB61CD31136F005 CRC64;
MATGSHTTTL LLAVALLGLP WPQEAGAFPA MPLSSLFANA VLRAQHLHQL AADTYKEFER
AYIPEGQRYS IQNTQAAFCF SETIPAPTGK DEAQQRSDME LLRFSLLLIQ SWLGPVQLLS
RVFTNSLVLG TLDRVYEKLK DLEEGIQALM RELEDGSPRV GQILKQTYDK FDTNLRSDDA
LLKNYGLLSC FKKDLHKAET YLRVMKCRRF VESSCAF