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SOMA_GALSE
ID   SOMA_GALSE              Reviewed;         217 AA.
AC   Q9GKA1;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Somatotropin;
DE   AltName: Full=Growth hormone;
DE   Flags: Precursor;
GN   Name=GH1;
OS   Galago senegalensis (Northern lesser bushbaby) (Senegal bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC   Galagidae; Galago.
OX   NCBI_TaxID=9465;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11141192; DOI=10.1093/oxfordjournals.molbev.a003719;
RA   Adkins R.M., Nekrutenko A., Li W.-H.;
RT   "Bushbaby growth hormone is much more similar to nonprimate growth hormones
RT   than to rhesus monkey and human growth hormones.";
RL   Mol. Biol. Evol. 18:55-61(2001).
CC   -!- FUNCTION: Plays an important role in growth control. Its major role in
CC       stimulating body growth is to stimulate the liver and other tissues to
CC       secrete IGF-1. It stimulates both the differentiation and proliferation
CC       of myoblasts. It also stimulates amino acid uptake and protein
CC       synthesis in muscle and other tissues.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; AF292938; AAG44952.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9GKA1; -.
DR   SMR; Q9GKA1; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034975; Somatotropin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Hormone; Metal-binding; Secreted; Signal; Zinc.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000250"
FT   CHAIN           27..217
FT                   /note="Somatotropin"
FT                   /id="PRO_0000032984"
FT   BINDING         46
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         199
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   DISULFID        79..190
FT                   /evidence="ECO:0000250"
FT   DISULFID        207..215
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   217 AA;  24481 MW;  2FB61CD31136F005 CRC64;
     MATGSHTTTL LLAVALLGLP WPQEAGAFPA MPLSSLFANA VLRAQHLHQL AADTYKEFER
     AYIPEGQRYS IQNTQAAFCF SETIPAPTGK DEAQQRSDME LLRFSLLLIQ SWLGPVQLLS
     RVFTNSLVLG TLDRVYEKLK DLEEGIQALM RELEDGSPRV GQILKQTYDK FDTNLRSDDA
     LLKNYGLLSC FKKDLHKAET YLRVMKCRRF VESSCAF
 
 
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