SOMA_HORSE
ID SOMA_HORSE Reviewed; 216 AA.
AC P01245;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 2.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Somatotropin;
DE AltName: Full=Growth hormone;
DE Flags: Precursor;
GN Name=GH1;
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Pituitary;
RX PubMed=8206392; DOI=10.1016/0378-1119(94)90115-5;
RA Ascacio-Martinez J.A., Barrera-Saldana H.A.;
RT "Sequence of a cDNA encoding horse growth hormone.";
RL Gene 143:299-300(1994).
RN [2]
RP PROTEIN SEQUENCE OF 27-216.
RX PubMed=965151; DOI=10.1111/j.1399-3011.1976.tb02523.x;
RA Zakin M.M., Poskus E., Langton A.A., Ferrara P., Santome J.A.,
RA Dellacha J.M., Paladini A.C.;
RT "Primary structure of equine growth hormone.";
RL Int. J. Pept. Protein Res. 8:435-444(1976).
RN [3]
RP PRELIMINARY PROTEIN SEQUENCE OF 27-216.
RX PubMed=4747849; DOI=10.1016/0014-5793(73)80829-4;
RA Zakin M.M., Poskus E., Dellacha J.M., Paladini A.C., Santome J.A.;
RT "The amino acid sequence of equine growth hormone.";
RL FEBS Lett. 34:353-355(1973).
RN [4]
RP PROTEIN SEQUENCE OF 68-95 AND 183-216.
RX PubMed=11946725; DOI=10.1016/0014-5793(72)80458-7;
RA Zakin M.M., Poskus E., Dellacha J.M., Paladini A.C., Santome J.A.;
RT "Amino acid sequences around the cystine residues in equine growth
RT hormone.";
RL FEBS Lett. 25:77-82(1972).
RN [5]
RP PROTEIN SEQUENCE OF 202-216.
RX PubMed=4876100; DOI=10.1042/bj1090019;
RA Oliver L., Hartree A.S.;
RT "Amino acid sequences around the cystine residues in horse growth
RT hormone.";
RL Biochem. J. 109:19-24(1968).
CC -!- FUNCTION: Plays an important role in growth control. Its major role in
CC stimulating body growth is to stimulate the liver and other tissues to
CC secrete IGF-1. It stimulates both the differentiation and proliferation
CC of myoblasts. It also stimulates amino acid uptake and protein
CC synthesis in muscle and other tissues.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC {ECO:0000305}.
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DR EMBL; U02929; AAA21027.1; -; mRNA.
DR PIR; A91772; STHO.
DR RefSeq; NP_001075417.1; NM_001081948.1.
DR AlphaFoldDB; P01245; -.
DR SMR; P01245; -.
DR STRING; 9796.ENSECAP00000007142; -.
DR PaxDb; P01245; -.
DR GeneID; 100034180; -.
DR KEGG; ecb:100034180; -.
DR CTD; 2688; -.
DR InParanoid; P01245; -.
DR OrthoDB; 1190548at2759; -.
DR Proteomes; UP000002281; Unplaced.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR GO; GO:0005131; F:growth hormone receptor binding; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0048513; P:animal organ development; IBA:GO_Central.
DR GO; GO:0060396; P:growth hormone receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0045927; P:positive regulation of growth; IBA:GO_Central.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IBA:GO_Central.
DR GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR034975; Somatotropin.
DR InterPro; IPR001400; Somatotropin/Prolactin.
DR InterPro; IPR018116; Somatotropin_CS.
DR PANTHER; PTHR11417; PTHR11417; 1.
DR PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR Pfam; PF00103; Hormone_1; 1.
DR PRINTS; PR00836; SOMATOTROPIN.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Hormone; Metal-binding;
KW Phosphoprotein; Reference proteome; Secreted; Signal; Zinc.
FT SIGNAL 1..26
FT /evidence="ECO:0000269|PubMed:965151"
FT CHAIN 27..216
FT /note="Somatotropin"
FT /id="PRO_0000032987"
FT BINDING 45
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 198
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT MOD_RES 131
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P01241"
FT DISULFID 78..189
FT DISULFID 206..214
SQ SEQUENCE 216 AA; 24423 MW; 37AB3173834D11AC CRC64;
MAAGPRTSVL LAFGLLCLPW PQDVGAFPAM PLSSLFANAV LRAQHLHQLA ADTYKEFERA
YIPEGQRYSI QNAQAAFCFS ETIPAPTGKD EAQQRSDMEL LRFSLLLIQS WLGPVQLLSR
VFTNSLVFGT SDRVYEKLRD LEEGIQALMR ELEDGSPRAG QILKQTYDKF DTNLRSDDAL
LKNYGLLSCF KKDLHKAETY LRVMKCRRFV ESSCAF
