ID   SOMA_KATPE              Reviewed;         185 AA.
AC   P20391;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Somatotropin;
DE   AltName: Full=Growth hormone;
GN   Name=gh;
OS   Katsuwonus pelamis (Skipjack tuna) (Bonito).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Pelagiaria; Scombriformes; Scombridae; Katsuwonus.
OX   NCBI_TaxID=8226;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=3246482; DOI=10.1111/j.1399-3011.1988.tb01390.x;
RA   Noso T., Yasuda A., Kawazoe I., Takehara H., Takahasi A., Sakai K.,
RA   Kawauchi H.;
RT   "Isolation and characterization of growth hormone from a marine fish,
RT   bonito (Katsuwonus pelamis).";
RL   Int. J. Pept. Protein Res. 32:579-589(1988).
CC   -!- FUNCTION: Growth hormone plays an important role in growth control and
CC       is involved in the regulation of several anabolic processes. Implicated
CC       as an osmoregulatory substance important for seawater adaptation.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   PIR; JK0021; JK0021.
DR   AlphaFoldDB; P20391; -.
DR   SMR; P20391; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034975; Somatotropin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hormone; Metal-binding;
KW   Secreted; Zinc.
FT   CHAIN           1..185
FT                   /note="Somatotropin"
FT                   /id="PRO_0000181336"
FT   BINDING         167
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   DISULFID        52..158
FT                   /evidence="ECO:0000250"
FT   DISULFID        175..183
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   185 AA;  21235 MW;  DD5970CD81422C81 CRC64;
     QPITESQRLF SIAVSRVQNL HLLAQRLFSD FESSLQTQEQ RQLNKIFLQD FCNSDYIISP
     IDKHETQRSS VLKLLSISYR LVESWEFPSR SLSGAQRNQI SEKLSDLKMG IQLLIRANQD
     GAEMFADSSA LQLAPYGNYY QSLGGDESLR RNYELLACFK KDMHKVETYL MVAKCRLSPE
     ANCTL