SOMA_LARCR
ID SOMA_LARCR Reviewed; 204 AA.
AC Q9I9M4;
DT 16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 2.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Somatotropin;
DE AltName: Full=Growth hormone;
DE Flags: Precursor;
GN Name=gh;
OS Larimichthys crocea (Large yellow croaker) (Pseudosciaena crocea).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Sciaenidae; Larimichthys.
OX NCBI_TaxID=215358;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Pituitary;
RA Jiang S., Ma H., Huang Q., Rao P.;
RT "Cloning and sequencing of Pseudosciaena crocea growth hormone (GH) cDNA.";
RL Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Growth hormone plays an important role in growth control and
CC is involved in the regulation of several anabolic processes. Implicated
CC as an osmoregulatory substance important for seawater adaptation.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC {ECO:0000305}.
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DR EMBL; AF231941; AAF42928.2; -; mRNA.
DR RefSeq; NP_001290254.1; NM_001303325.1.
DR AlphaFoldDB; Q9I9M4; -.
DR SMR; Q9I9M4; -.
DR GeneID; 104931893; -.
DR KEGG; lco:104931893; -.
DR CTD; 2688; -.
DR eggNOG; ENOG502R5GJ; Eukaryota.
DR OrthoDB; 1190548at2759; -.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR034975; Somatotropin.
DR InterPro; IPR001400; Somatotropin/Prolactin.
DR InterPro; IPR018116; Somatotropin_CS.
DR PANTHER; PTHR11417; PTHR11417; 1.
DR PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR Pfam; PF00103; Hormone_1; 1.
DR PRINTS; PR00836; SOMATOTROPIN.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Hormone; Metal-binding; Pyrrolidone carboxylic acid;
KW Secreted; Signal; Zinc.
FT SIGNAL 1..17
FT /evidence="ECO:0000250"
FT CHAIN 18..204
FT /note="Somatotropin"
FT /id="PRO_0000033050"
FT BINDING 36
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 186
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT MOD_RES 18
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT DISULFID 69..177
FT /evidence="ECO:0000250"
FT DISULFID 194..202
FT /evidence="ECO:0000250"
SQ SEQUENCE 204 AA; 23306 MW; F311F8C676D15CFD CRC64;
MDRVLLLLSV LTLGVSSQQI IENQRLFSMD ATRVQHLHLL AQRLFSDFES SLQTEEQRQL
NKIFLQDFCN SDYIISPIDK HETQRSSVLK LLSISYRLVE SWEFPSRSLS GGSAPRNQIS
PKLSELKMGI LLLIRANQDA AEIFPDNSAL QLAPYGNYYQ SLSGEESLRR TYELLACFKK
DMHKVETYLT VAKCRLSPEA NCTL