ID   SOMA_LATCA              Reviewed;         204 AA.
AC   Q01283; Q91067;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   16-NOV-2001, sequence version 2.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Somatotropin;
DE   AltName: Full=Growth hormone;
DE   Flags: Precursor;
GN   Name=gh;
OS   Lates calcarifer (Barramundi) (Holocentrus calcarifer).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Carangaria incertae sedis; Centropomidae; Lates.
OX   NCBI_TaxID=8187;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=1777674; DOI=10.3109/10425179109039680;
RA   Knibb W., Robins A., Crocker L., Rizzon J., Heyward A., Wells J.;
RT   "Molecular cloning and sequencing of Australian black bream Acanthopagrus
RT   butcheri and barramundi Lates calcarifer fish growth hormone cDNA using
RT   polymerase chain reaction.";
RL   DNA Seq. 2:121-123(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Liver;
RX   PubMed=7557439; DOI=10.1016/0378-1119(95)92858-5;
RA   Yowe D.L., Epping R.J.;
RT   "Cloning of the barramundi growth hormone-encoding gene: a comparative
RT   analysis of higher and lower vertebrate GH genes.";
RL   Gene 162:255-259(1995).
CC   -!- FUNCTION: Growth hormone plays an important role in growth control and
CC       is involved in the regulation of several anabolic processes. Implicated
CC       as an osmoregulatory substance important for seawater adaptation.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; X59378; CAA42022.1; -; mRNA.
DR   EMBL; U16816; AAC59692.1; -; Genomic_DNA.
DR   PIR; JC4261; JC4261.
DR   RefSeq; XP_018516903.1; XM_018661387.1.
DR   AlphaFoldDB; Q01283; -.
DR   SMR; Q01283; -.
DR   STRING; 8187.ENSLCAP00010042507; -.
DR   Ensembl; ENSLCAT00010043559; ENSLCAP00010042508; ENSLCAG00010019797.
DR   GeneID; 108873234; -.
DR   KEGG; lcf:108873234; -.
DR   CTD; 2688; -.
DR   GeneTree; ENSGT00950000182818; -.
DR   OrthoDB; 1190548at2759; -.
DR   Proteomes; UP000314980; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034975; Somatotropin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Metal-binding; Pyrrolidone carboxylic acid;
KW   Reference proteome; Secreted; Signal; Zinc.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000250"
FT   CHAIN           18..204
FT                   /note="Somatotropin"
FT                   /id="PRO_0000033029"
FT   BINDING         36
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         186
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         18
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250"
FT   DISULFID        69..177
FT                   /evidence="ECO:0000250"
FT   DISULFID        194..202
FT                   /evidence="ECO:0000250"
FT   CONFLICT        59..60
FT                   /note="QL -> HV (in Ref. 1; CAA42022)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   204 AA;  23100 MW;  B7A949BC5CA8DBE5 CRC64;
     MDRVVLLLSV LSLGVSSQPI TDSQRLFSIA VSRVQHLHLL AQRRFSEFES SLQTEEQRQL
     NKIFLQDFCN SDYIISPIDK HETQRSSVLK LLSISYRLVE SWEFSSRSLS GGSAPRDQIS
     PKLSELKTGI LLLIRANQDG AEMFSDSSAL QLAPYGNYYQ SLGADESLRR TYELLACFKK
     DMHKVETYLT VAKCRLSPEA NCTL