SOMA_LEPOS
ID SOMA_LEPOS Reviewed; 211 AA.
AC P79885;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Somatotropin;
DE AltName: Full=Growth hormone;
DE Flags: Precursor;
GN Name=gh;
OS Lepisosteus osseus (Long-nosed gar) (Esox osseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=34771;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Pituitary;
RX PubMed=8672235; DOI=10.1677/jme.0.0160073;
RA Rubin D.A., Youson J.H., Marra L.E., Dores R.M.;
RT "Cloning of a gar (Lepisosteus osseus) GH cDNA: trends in actinopterygian
RT GH structure.";
RL J. Mol. Endocrinol. 16:73-80(1996).
CC -!- FUNCTION: Growth hormone plays an important role in growth control and
CC is involved in the regulation of several anabolic processes. Implicated
CC as an osmoregulatory substance important for seawater adaptation.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC {ECO:0000305}.
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DR EMBL; S82528; AAB37388.1; -; mRNA.
DR AlphaFoldDB; P79885; -.
DR SMR; P79885; -.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR034975; Somatotropin.
DR InterPro; IPR001400; Somatotropin/Prolactin.
DR InterPro; IPR018116; Somatotropin_CS.
DR PANTHER; PTHR11417; PTHR11417; 1.
DR PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR Pfam; PF00103; Hormone_1; 1.
DR PRINTS; PR00836; SOMATOTROPIN.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Hormone; Metal-binding; Secreted; Signal; Zinc.
FT SIGNAL 1..23
FT /evidence="ECO:0000250"
FT CHAIN 24..211
FT /note="Somatotropin"
FT /id="PRO_0000033030"
FT BINDING 40
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 193
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT DISULFID 73..184
FT /evidence="ECO:0000250"
FT DISULFID 201..209
FT /evidence="ECO:0000250"
SQ SEQUENCE 211 AA; 23999 MW; 85F55990954ED9EB CRC64;
MASGFLLCPV LLAVFFMSPV EVGAFPLYSL FTNAVIRAQH LHQLAADIYK DFERTYVPEE
QRQSSKSSPS AICYSESIPA PTGKDEAQQR SDVELLRFSL ALIQSWISPL QTLSRVFSNS
LVFGTSDRIF EKLQDLERGI VTLTREIDEG SPRIAAFLTL TYEKFDTNLR NDDALMKNYG
LLACFKKDMH KVETYLKVMK CRRFVESNCT L