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SOMA_LEPOS
ID   SOMA_LEPOS              Reviewed;         211 AA.
AC   P79885;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Somatotropin;
DE   AltName: Full=Growth hormone;
DE   Flags: Precursor;
GN   Name=gh;
OS   Lepisosteus osseus (Long-nosed gar) (Esox osseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC   Lepisosteus.
OX   NCBI_TaxID=34771;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=8672235; DOI=10.1677/jme.0.0160073;
RA   Rubin D.A., Youson J.H., Marra L.E., Dores R.M.;
RT   "Cloning of a gar (Lepisosteus osseus) GH cDNA: trends in actinopterygian
RT   GH structure.";
RL   J. Mol. Endocrinol. 16:73-80(1996).
CC   -!- FUNCTION: Growth hormone plays an important role in growth control and
CC       is involved in the regulation of several anabolic processes. Implicated
CC       as an osmoregulatory substance important for seawater adaptation.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; S82528; AAB37388.1; -; mRNA.
DR   AlphaFoldDB; P79885; -.
DR   SMR; P79885; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034975; Somatotropin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Metal-binding; Secreted; Signal; Zinc.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   CHAIN           24..211
FT                   /note="Somatotropin"
FT                   /id="PRO_0000033030"
FT   BINDING         40
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         193
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   DISULFID        73..184
FT                   /evidence="ECO:0000250"
FT   DISULFID        201..209
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   211 AA;  23999 MW;  85F55990954ED9EB CRC64;
     MASGFLLCPV LLAVFFMSPV EVGAFPLYSL FTNAVIRAQH LHQLAADIYK DFERTYVPEE
     QRQSSKSSPS AICYSESIPA PTGKDEAQQR SDVELLRFSL ALIQSWISPL QTLSRVFSNS
     LVFGTSDRIF EKLQDLERGI VTLTREIDEG SPRIAAFLTL TYEKFDTNLR NDDALMKNYG
     LLACFKKDMH KVETYLKVMK CRRFVESNCT L
 
 
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