ID   SOMA_LOXAF              Reviewed;         190 AA.
AC   P20392;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Somatotropin;
DE   AltName: Full=Growth hormone;
GN   Name=GH1;
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785;
RN   [1]
RP   PROTEIN SEQUENCE.
RA   Hulmes J.D., Miedel M.C., Li C.H., Pan Y.C.E.;
RT   "Primary structure of elephant growth hormone.";
RL   Int. J. Pept. Protein Res. 33:368-372(1989).
CC   -!- FUNCTION: Plays an important role in growth control. Its major role in
CC       stimulating body growth is to stimulate the liver and other tissues to
CC       secrete IGF-1. It stimulates both the differentiation and proliferation
CC       of myoblasts. It also stimulates amino acid uptake and protein
CC       synthesis in muscle and other tissues.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   PIR; JK0219; JK0219.
DR   AlphaFoldDB; P20392; -.
DR   SMR; P20392; -.
DR   STRING; 9785.ENSLAFP00000016054; -.
DR   eggNOG; ENOG502R5GJ; Eukaryota.
DR   HOGENOM; CLU_088274_2_1_1; -.
DR   InParanoid; P20392; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034975; Somatotropin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hormone; Metal-binding;
KW   Phosphoprotein; Reference proteome; Secreted; Zinc.
FT   CHAIN           1..190
FT                   /note="Somatotropin"
FT                   /id="PRO_0000181330"
FT   BINDING         19
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         172
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         105
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01241"
FT   DISULFID        52..163
FT                   /evidence="ECO:0000250"
FT   DISULFID        180..188
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   190 AA;  21761 MW;  05B860813DB741F2 CRC64;
     FPAMPLSSLF ANAVLRAQHL HQLAADTYKE FERAYIPEGQ RYSIQNAQAA FCFSETIPAP
     TGKDEAQQRS DVELLRFSLL LIQSWLGPVQ FLSRVFTNSL VFGTSDRVYE KLKDLEEGIQ
     ALMRELEDGS PRPGQVLKQT YDKFDTNMRS DDALLKNYGL LSCFKKDLHK AETYLRVMKC
     RRFVESSCAF