ID   SOMA_MACMU              Reviewed;         217 AA.
AC   P33093;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 2.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Somatotropin;
DE   AltName: Full=Growth hormone;
DE            Short=GH;
DE            Short=GH-N;
DE   AltName: Full=Growth hormone 1;
DE   AltName: Full=Pituitary growth hormone;
DE   Flags: Precursor;
GN   Name=GH1;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8404617; DOI=10.1210/endo.133.4.8404617;
RA   Golos T.G., Durning M., Fisher J.M., Fowler P.D.;
RT   "Cloning of four growth hormone/chorionic somatomammotropin-related
RT   complementary deoxyribonucleic acids differentially expressed during
RT   pregnancy in the rhesus monkey placenta.";
RL   Endocrinology 133:1744-1752(1993).
RN   [2]
RP   PROTEIN SEQUENCE OF 27-217.
RX   PubMed=3080959; DOI=10.1016/0003-9861(86)90216-x;
RA   Li C.H., Chung D., Lahm H.W., Stein S.;
RT   "The primary structure of monkey pituitary growth hormone.";
RL   Arch. Biochem. Biophys. 245:287-291(1986).
CC   -!- FUNCTION: Plays an important role in growth control. Its major role in
CC       stimulating body growth is to stimulate the liver and other tissues to
CC       secrete IGF-1. It stimulates both the differentiation and proliferation
CC       of myoblasts. It also stimulates amino acid uptake and protein
CC       synthesis in muscle and other tissues.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; L16556; AAA18842.1; -; mRNA.
DR   PIR; I67410; I67410.
DR   RefSeq; NP_001036203.1; NM_001042738.1.
DR   AlphaFoldDB; P33093; -.
DR   BMRB; P33093; -.
DR   SMR; P33093; -.
DR   Ensembl; ENSMMUT00000086046; ENSMMUP00000061131; ENSMMUG00000039847.
DR   GeneID; 718156; -.
DR   KEGG; mcc:718156; -.
DR   CTD; 2688; -.
DR   VEuPathDB; HostDB:ENSMMUG00000039847; -.
DR   GeneTree; ENSGT00950000182818; -.
DR   InParanoid; P33093; -.
DR   Proteomes; UP000006718; Chromosome 16.
DR   Bgee; ENSMMUG00000039847; Expressed in adipose tissue and 4 other tissues.
DR   ExpressionAtlas; P33093; baseline.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR   GO; GO:0005131; F:growth hormone receptor binding; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0048513; P:animal organ development; IBA:GO_Central.
DR   GO; GO:0060396; P:growth hormone receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0045927; P:positive regulation of growth; IBA:GO_Central.
DR   GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR   GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IBA:GO_Central.
DR   GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hormone; Metal-binding;
KW   Phosphoprotein; Reference proteome; Secreted; Signal; Zinc.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000269|PubMed:3080959"
FT   CHAIN           27..217
FT                   /note="Somatotropin"
FT                   /id="PRO_0000032989"
FT   BINDING         44
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         200
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         132
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01241"
FT   DISULFID        79..191
FT                   /evidence="ECO:0000250"
FT   DISULFID        208..215
FT                   /evidence="ECO:0000250"
FT   CONFLICT        100
FT                   /note="E -> Q (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        179
FT                   /note="N -> D (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   217 AA;  24913 MW;  2C5180341EEC46D0 CRC64;
     MAAGSRTSLL LAFALLCLPW LQEGSAFPTI PLSRLFDNAM LRAHRLHQLA FDTYQEFEEA
     YIPKEQKYSF LQNPQTSLCF SESIPTPSNR EETQQKSNLE LLRISLLLIQ SWLEPVQFLR
     SVFANSLVYG TSYSDVYDLL KDLEEGIQTL MGRLEDGSSR TGQIFKQTYS KFDTNSHNND
     ALLKNYGLLY CFRKDMDKIE TFLRIVQCRS VEGSCGF