ID   SOMA_MELGA              Reviewed;         216 AA.
AC   P22077;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1991, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Somatotropin;
DE   AltName: Full=Growth hormone;
DE   Flags: Precursor;
GN   Name=GH;
OS   Meleagris gallopavo (Wild turkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Meleagridinae; Meleagris.
OX   NCBI_TaxID=9103;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=2125220; DOI=10.1016/s0006-291x(05)80880-0;
RA   Foster D.N., Kim S.U., Enyeart J.J., Foster L.K.;
RT   "Nucleotide sequence of the complementary DNA for turkey growth hormone.";
RL   Biochem. Biophys. Res. Commun. 173:967-975(1990).
RN   [2]
RP   ERRATUM OF PUBMED:2125220.
RX   PubMed=2018514; DOI=10.1016/0006-291x(91)91626-n;
RA   Foster D.N., Kim S.U., Enyeart J.J., Foster L.K.;
RL   Biochem. Biophys. Res. Commun. 175:729-731(1991).
CC   -!- FUNCTION: Growth hormone plays an important role in growth control.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Pituitary gland.
CC   -!- INDUCTION: By growth hormone releasing factor (GRF).
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; M33697; AAA49628.1; -; mRNA.
DR   PIR; JC1514; JC1514.
DR   AlphaFoldDB; P22077; -.
DR   SMR; P22077; -.
DR   Ensembl; ENSMGAT00000037054; ENSMGAP00000031379; ENSMGAG00000008772.
DR   GeneTree; ENSGT00950000182818; -.
DR   InParanoid; P22077; -.
DR   Proteomes; UP000001645; Chromosome 29.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0097153; F:cysteine-type endopeptidase activity involved in apoptotic process; ISS:AgBase.
DR   GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; ISS:AgBase.
DR   GO; GO:0010629; P:negative regulation of gene expression; ISS:AgBase.
DR   GO; GO:0035846; P:oviduct epithelium development; ISS:AgBase.
DR   GO; GO:0010628; P:positive regulation of gene expression; ISS:AgBase.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034975; Somatotropin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Metal-binding; Reference proteome; Secreted;
KW   Signal; Zinc.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000250"
FT   CHAIN           26..216
FT                   /note="Somatotropin"
FT                   /id="PRO_0000033005"
FT   BINDING         45
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         198
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   DISULFID        78..189
FT                   /evidence="ECO:0000250"
FT   DISULFID        206..214
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   216 AA;  24747 MW;  D901C9DBE07CB467 CRC64;
     MAPGSWFSPL LIAVVTLGLP QGAAATFPTM PLSNLFTNAV LRAQHLHLLA AETYKEFERT
     YIPEDQRYTN KNSQAAFCYS ETIPAPTGKD DAQQKSDMEL LRFSLVLIQS WLTPMQYLSK
     VFTNNLVFGT SDRVFEKLKD LEEGIQALMR ELEDRSPRGP QLLRPTYDRF DIHLRSEDAL
     LKNYGLLSCF KKDLHKVETY LKVMKCRRFG ESNCNI