SOMA_MESAU
ID SOMA_MESAU Reviewed; 216 AA.
AC P37886;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Somatotropin;
DE AltName: Full=Growth hormone;
DE Flags: Precursor;
GN Name=GH1; Synonyms=GH;
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1954881; DOI=10.1210/endo-129-6-2965;
RA Southard J.N., Sanchez-Jimenez F., Campbell G.T., Talamantes F.;
RT "Sequence and expression of hamster prolactin and growth hormone messenger
RT RNAs.";
RL Endocrinology 129:2965-2971(1991).
CC -!- FUNCTION: Plays an important role in growth control. Its major role in
CC stimulating body growth is to stimulate the liver and other tissues to
CC secrete IGF-1. It stimulates both the differentiation and proliferation
CC of myoblasts. It also stimulates amino acid uptake and protein
CC synthesis in muscle and other tissues.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC {ECO:0000305}.
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DR EMBL; S66299; AAB20368.1; -; mRNA.
DR PIR; B49159; B49159.
DR RefSeq; NP_001268544.1; NM_001281615.1.
DR AlphaFoldDB; P37886; -.
DR SMR; P37886; -.
DR STRING; 10036.XP_005070071.1; -.
DR GeneID; 101843583; -.
DR CTD; 2688; -.
DR eggNOG; ENOG502R5GJ; Eukaryota.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR034975; Somatotropin.
DR InterPro; IPR001400; Somatotropin/Prolactin.
DR InterPro; IPR018116; Somatotropin_CS.
DR PANTHER; PTHR11417; PTHR11417; 1.
DR PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR Pfam; PF00103; Hormone_1; 1.
DR PRINTS; PR00836; SOMATOTROPIN.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Hormone; Metal-binding; Phosphoprotein; Reference proteome;
KW Secreted; Signal; Zinc.
FT SIGNAL 1..26
FT /evidence="ECO:0000250"
FT CHAIN 27..216
FT /note="Somatotropin"
FT /id="PRO_0000032990"
FT BINDING 45
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 198
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT MOD_RES 131
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P01241"
FT DISULFID 78..189
FT /evidence="ECO:0000250"
FT DISULFID 206..214
FT /evidence="ECO:0000250"
SQ SEQUENCE 216 AA; 24690 MW; 3B69CE32AB6F1166 CRC64;
MAADSQTSRL LTFTLLCLLW PQEAGAFPAM PLSSLFANAV LRAQHLHQLA ADTYKEFERA
YIPEGQRYSI QNAQTAFCFS ETIPAPTGKE EAQQRSDMEL LRFSLLLIQS WLGPVQFLSR
IFTNSLMFGT SDRVYEKLKD LEEGIQALMQ ELEDGSPRVG QILKQTYDKF DTNMRSDDAL
LKNYGLLSCF KKDLHKAETY LRVMKCRRFV ESSCAF