ID   SOMA_MISMI              Reviewed;         210 AA.
AC   Q9W6J5;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Somatotropin;
DE   AltName: Full=Growth hormone;
DE   Flags: Precursor;
GN   Name=gh;
OS   Misgurnus mizolepis (Chinese weatherloach).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cobitidae; Cobitinae; Misgurnus.
OX   NCBI_TaxID=93600;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10672931;
RA   Noh J.K., Cho K.N., Nam Y.K., Kim D.S., Kim C.G.;
RT   "Genomic organization and sequence of the mud loach (Misgurnus mizolepis)
RT   growth hormone gene: a comparative analysis of teleost growth hormone
RT   genes.";
RL   Mol. Cells 9:638-645(1999).
CC   -!- FUNCTION: Growth hormone plays an important role in growth control and
CC       is involved in the regulation of several anabolic processes. Implicated
CC       as an osmoregulatory substance important for seawater adaptation.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; AF133815; AAD31845.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9W6J5; -.
DR   SMR; Q9W6J5; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034975; Somatotropin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Hormone; Metal-binding; Secreted; Signal; Zinc.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000250"
FT   CHAIN           23..210
FT                   /note="Somatotropin"
FT                   /id="PRO_0000033031"
FT   BINDING         38
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         192
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   DISULFID        71..183
FT                   /evidence="ECO:0000250"
FT   DISULFID        200..208
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   210 AA;  23596 MW;  13146619F65FE9D3 CRC64;
     MAKALVLLSL VLVSVFVNNG TASENQRLFN NAVIRVQHLH QLAAKMINDF EDSLLPEERR
     QLSKIFPLSF CNSDSIEAPT GKDETQKSSV LKLLRISFRL IESWEYPSQT LSGTISNSLT
     IGNPSQITEK LADLKVGISV LIKGCLDGQP NMDDNDSLPL PFEDFYLTLG ENNLRESFRL
     LACFKKDMHK VETYLRVANC RRSLDSNCTL