SOMA_MONDO
ID SOMA_MONDO Reviewed; 215 AA.
AC Q9GL60;
DT 16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Somatotropin;
DE AltName: Full=Growth hormone;
DE Flags: Precursor;
GN Name=GH1;
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Pituitary;
RA Kacsoh B.;
RT "Cloning and characterization of pituitary growth hormone precursor cDNA
RT from the marsupial, Monodelphis domestica.";
RL Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays an important role in growth control. Its major role in
CC stimulating body growth is to stimulate the liver and other tissues to
CC secrete IGF-1. It stimulates both the differentiation and proliferation
CC of myoblasts. It also stimulates amino acid uptake and protein
CC synthesis in muscle and other tissues (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC {ECO:0000305}.
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DR EMBL; AF312023; AAG27732.1; -; mRNA.
DR RefSeq; NP_001028165.1; NM_001032993.1.
DR AlphaFoldDB; Q9GL60; -.
DR SMR; Q9GL60; -.
DR STRING; 13616.ENSMODP00000012310; -.
DR GeneID; 554243; -.
DR KEGG; mdo:554243; -.
DR CTD; 2688; -.
DR eggNOG; ENOG502R5GJ; Eukaryota.
DR InParanoid; Q9GL60; -.
DR OrthoDB; 1190548at2759; -.
DR Proteomes; UP000002280; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR034975; Somatotropin.
DR InterPro; IPR001400; Somatotropin/Prolactin.
DR InterPro; IPR018116; Somatotropin_CS.
DR PANTHER; PTHR11417; PTHR11417; 1.
DR PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR Pfam; PF00103; Hormone_1; 1.
DR PRINTS; PR00836; SOMATOTROPIN.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE 2: Evidence at transcript level;
KW Hormone; Metal-binding; Phosphoprotein; Reference proteome; Secreted;
KW Signal; Zinc.
FT SIGNAL 1..25
FT /evidence="ECO:0000250"
FT CHAIN 26..215
FT /note="Somatotropin"
FT /id="PRO_0000032991"
FT BINDING 44
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 197
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT MOD_RES 130
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P01241"
SQ SEQUENCE 215 AA; 24384 MW; B704C6214A329010 CRC64;
MAPGMRVCLL LLIAFTLLGP QRAAAFPAMP LSSLFANAVL RAQHLHQLVA DTYKEFERTY
IPEAQRHSIQ STQTAFCFSE TIPAPTGKDE AQQRSDVELL RFSLLLIQSW LSPVQFLSRV
FTNSLVFGTS DRVYEKLRDL EEGIQALMQE LEDGSSRGGL VLKTTYDKFD TNLRSDEALL
KNYGLLSCFK KDLHKAETYL RVMECRRFVE SSCAF