ID   SOMA_NEOVI              Reviewed;         216 AA.
AC   P19795;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Somatotropin;
DE   AltName: Full=Growth hormone;
DE   Flags: Precursor;
GN   Name=GH1; Synonyms=GH;
OS   Neovison vison (American mink) (Mustela vison).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae; Mustelinae;
OC   Neogale.
OX   NCBI_TaxID=452646;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=2243786; DOI=10.1093/nar/18.21.6424;
RA   Shoji K., Ohara E., Watahiki M., Yoneda Y.;
RT   "Cloning and nucleotide sequence of a cDNA encoding the mink growth
RT   hormone.";
RL   Nucleic Acids Res. 18:6424-6424(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 12-216.
RA   Perelygina L.M., Baricheva E.M., Sebeleva T.E., Kokoza V.A.;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 27-216.
RX   PubMed=2268323; DOI=10.1016/s0006-291x(05)80913-1;
RA   Harada Y., Tatsumi H., Nakano E., Umezu M.;
RT   "Cloning and sequence analysis of mink growth hormone cDNA.";
RL   Biochem. Biophys. Res. Commun. 173:1200-1204(1990).
CC   -!- FUNCTION: Plays an important role in growth control. Its major role in
CC       stimulating body growth is to stimulate the liver and other tissues to
CC       secrete IGF-1. It stimulates both the differentiation and proliferation
CC       of myoblasts. It also stimulates amino acid uptake and protein
CC       synthesis in muscle and other tissues.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; X56120; CAA39585.1; -; mRNA.
DR   EMBL; X59786; CAA42448.2; -; mRNA.
DR   EMBL; M62901; AAA30964.1; -; mRNA.
DR   PIR; S12128; A37782.
DR   AlphaFoldDB; P19795; -.
DR   SMR; P19795; -.
DR   Ensembl; ENSNVIT00000035564; ENSNVIP00000030700; ENSNVIG00000023639.
DR   GeneTree; ENSGT00950000182818; -.
DR   Proteomes; UP000694425; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034975; Somatotropin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Metal-binding; Phosphoprotein; Reference proteome;
KW   Secreted; Signal; Zinc.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000250"
FT   CHAIN           27..216
FT                   /note="Somatotropin"
FT                   /id="PRO_0000032993"
FT   BINDING         45
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         198
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         131
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01241"
FT   DISULFID        78..189
FT                   /evidence="ECO:0000250"
FT   DISULFID        206..214
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   216 AA;  24469 MW;  A75B96AC94EC257F CRC64;
     MAAGPRNSML LVFALLSLPW PQEVGAFPAM PLSSLFANAV LRAQHLHQLA ADTYKDFERA
     YIPEGQRYSI QNAQAAFCFS ETIPAPTGKD EAQQRSDMEL LRFSLLLIQS WLGPVQFLSR
     VFTNSLVFGT SDRVYEKLKD LEEGIQALMR ELEDGSPRAG PILKQTYDKF DTNLRSDDAL
     LKNYGLLSCF KKDLHKAETY LRVMKCRRFV ESSCAF