ID   SOMA_ONCKI              Reviewed;         210 AA.
AC   P10607;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Somatotropin;
DE   AltName: Full=Growth hormone;
DE   Flags: Precursor;
GN   Name=gh;
OS   Oncorhynchus kisutch (Coho salmon) (Salmo kisutch).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8019;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3267230; DOI=10.1016/0378-1119(88)90460-x;
RA   Gonzalez-Villasenor L.I., Zhang P., Chen T.T., Powers D.A.;
RT   "Molecular cloning and sequencing of coho salmon growth hormone cDNA.";
RL   Gene 65:239-246(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 23-64.
RX   PubMed=2449377; DOI=10.1016/0016-6480(87)90077-3;
RA   Nicoll C.S., Steiny S.S., King D.S., Nishioka R.S., Mayer G.L.,
RA   Eberhardt N.L., Baxter J.D., Yamanaka M.K., Miller J.A., Seilhamer J.J.;
RT   "The primary structure of coho salmon growth hormone and its cDNA.";
RL   Gen. Comp. Endocrinol. 68:387-399(1987).
CC   -!- FUNCTION: Growth hormone plays an important role in growth control and
CC       is involved in the regulation of several anabolic processes. Implicated
CC       as an osmoregulatory substance important for seawater adaptation.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; M19999; AAA49402.1; -; mRNA.
DR   PIR; JT0305; STONC.
DR   AlphaFoldDB; P10607; -.
DR   SMR; P10607; -.
DR   OrthoDB; 1190548at2759; -.
DR   Proteomes; UP000694557; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0055074; P:calcium ion homeostasis; ISS:AgBase.
DR   GO; GO:0042538; P:hyperosmotic salinity response; ISS:AgBase.
DR   GO; GO:0010960; P:magnesium ion homeostasis; ISS:AgBase.
DR   GO; GO:0045919; P:positive regulation of cytolysis; ISS:AgBase.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; ISS:AgBase.
DR   GO; GO:0032930; P:positive regulation of superoxide anion generation; ISS:AgBase.
DR   GO; GO:0002637; P:regulation of immunoglobulin production; ISS:AgBase.
DR   GO; GO:0055078; P:sodium ion homeostasis; ISS:AgBase.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034975; Somatotropin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hormone; Metal-binding;
KW   Reference proteome; Secreted; Signal; Zinc.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000269|PubMed:2449377"
FT   CHAIN           23..210
FT                   /note="Somatotropin"
FT                   /id="PRO_0000033034"
FT   BINDING         38
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         192
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   DISULFID        71..183
FT                   /evidence="ECO:0000250"
FT   DISULFID        200..208
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   210 AA;  23765 MW;  12D36A2AFFAFD63B CRC64;
     MGQVFLLMPV LLVSCFLSQG AAIENQRLFN IAVSRVQHLH LLAQKMFNDF DGTLLPDERR
     QLNKIFLLDF CNSDSIVSPV DKHETQKSSV LKLLHISFRL IESWEYPSQT LIISNSLLVG
     NANQISEKLS DLKVGINLLI MGSQDGLLSL DDNDSQQLPR YGNYYQNPGG DGNVRRNYEL
     LACFKKDMHK VETYLTVAKC RKSLEANCTL