ID   SOMA_ONCMA              Reviewed;         210 AA.
AC   Q9DGG5;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Somatotropin;
DE   AltName: Full=Growth hormone;
DE   Flags: Precursor;
GN   Name=gh;
OS   Oncorhynchus masou (Cherry salmon) (Masu salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8020;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RA   Shoji K., Watahiki M., Hirano H., Yoneda Y.;
RT   "cDNA cloning and primary structure of masu salmon (Oncorhynchus masou)
RT   growth hormone.";
RL   Submitted (AUG-1991) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Growth hormone plays an important role in growth control and
CC       is involved in the regulation of several anabolic processes. Implicated
CC       as an osmoregulatory substance important for seawater adaptation.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; X59762; CAA42431.1; -; mRNA.
DR   AlphaFoldDB; Q9DGG5; -.
DR   SMR; Q9DGG5; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0055074; P:calcium ion homeostasis; ISS:AgBase.
DR   GO; GO:0042538; P:hyperosmotic salinity response; ISS:AgBase.
DR   GO; GO:0010960; P:magnesium ion homeostasis; ISS:AgBase.
DR   GO; GO:0045919; P:positive regulation of cytolysis; ISS:AgBase.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; ISS:AgBase.
DR   GO; GO:0032930; P:positive regulation of superoxide anion generation; ISS:AgBase.
DR   GO; GO:0002637; P:regulation of immunoglobulin production; ISS:AgBase.
DR   GO; GO:0055078; P:sodium ion homeostasis; ISS:AgBase.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR034975; Somatotropin.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Metal-binding; Secreted; Signal; Zinc.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000250"
FT   CHAIN           23..210
FT                   /note="Somatotropin"
FT                   /id="PRO_0000033035"
FT   BINDING         38
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         192
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   DISULFID        71..183
FT                   /evidence="ECO:0000250"
FT   DISULFID        200..208
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   210 AA;  23845 MW;  D24BFD6B38DC53CA CRC64;
     MGQVFLLMPV LLVSCFLSHG AAIENQRLFN IAVSRVQHLH LLAQKMFNDF DGTLLPDERR
     QLNKIFLLDF CNSDSIVSPI DKHETQKSSV LKLLHISFRL IESWEYPSQT LIISNSLMVR
     NANQISEKLS DLKVGINLLI TGNQDGVLSL DDNDSQQLPP YGNYYQNLGG DGNVRRNYEL
     LACFKKDMHK VETYLTVAKC RKSLEANCTL